Professor. Thashi Chang

MBBS, MD, MRCP(UK), MRCP(UK)(Neurology), DPhil (Oxon), FCCP, FRCP(Lond)

  • Senior Lecturer, Department of Clinical Medicine
  • Consultant Neurologist

CONTACT DETAILS

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QUALIFICATIONS

  • MBBS – University of Colombo 1996
  • MD – University of Colombo 2002
  • MRCP - London 2004
  • DPhil - Oxford 2008 

RESEARCH INTERESTS

  • Neuroimmunological disorders
  • CNS infections
  • General Neurology

BIOGRAPHY

Thashi Chang is a Senior Lecturer and a Board-certified Specialist in Neurology. He is an alumnus of the University of Colombo and joined the Department of Clinical Medicine in 2001. He is a Commonwealth Scholar and obtained his doctorate in Clinical Neurology from the University of Oxford, United Kingdom.

APPOINTMENTS

  • Academic Visitor, University of Oxford, United Kingdom, 2008 to date
  • Joint Secretary of the Association of Sri Lankan Neurologists, 2010 – 2012
  • Council member of the Association of Sri Lankan Neurologists, 2009 – 2010
  • Secretary of the Specialty Board in Neurology, Postgraduate Institute of Medicine, University of Colombo, September 2009 to date
  • Secretary of the Board of Study in Sports Medicine, Postgraduate Institute of  Medicine, University of Colombo, May 2010 to date
  • The Postgraduate Institute of Medicine, University of Colombo, March 2010
  • Member, Sports Board, University of Colombo, 2010 – to date
  • Council Member – Faculty of Medicine Teachers’ Association 2010 – 2011
  • Committee Member – Medical Library, Faculty of Medicine, University of Colombo
  • Member of the Movement Disorder Society (the international society for Parkinson disease and other movement disorders)
  • Life member of the Sri Lanka Medical Association (SLMA)
  • Life member of the Ceylon College of Physicians (CCP)
  • Life member of the Association of Sri Lankan Neurologists (ASN)
  • Life member of the National Stroke Association of Sri Lanka (NSASL)
  • Life member of the Sri Lankan League against Epilepsy (SLLAE)
  • Founder member of the Colombo Medical School Alumni Association (CoMSAA)
  • Alumnus of the University of Oxford, United Kingdom
  • Advisory Editor to the International Journal of Critical Illness and Injury Science: official publication of international network of critical illness and injury trial experts. http://www.ijciis.org/ (2011 to date).
  • Member of the Editorial Board of the Sri Lanka Journal of Neurology (2012)

AWARDS AND DISTINCTIONS

  • Best Poster Award, Asia Pacific Stroke Conference 2011.
  • EV Pieris Memorial Oration, Ceylon College of Physicians 2011.
  • Commonwealth Scholarship, University of Oxford, UK, 2003 – 2006.
  • Graduate Scholarship, St Hugh’s College, Oxford, UK, 2005.
  • International Society of Neuroimmunology (ISNI) Travel Award, 2004.
  • Award of Excellence in Research, University of Colombo, 1999.
  • Presidential Award for research in the year 1999.
  • Wilson Pieris award, Sri Lanka Medical Association, 1997.
  • Commonwealth Foundation Medical Electives Scholarship, 1996.

Undergraduate

  • First Class Honours at 2nd MBBS, 3rd MBBS and Final MBBS with Distinctions in Biochemistry,    Physiology, Microbiology, Parasitology, Pathology, Pharmacology, Community Medicine, Medicine,  Surgery and Paediatrics. 
  • Dr Vaitialingam Gold Medal for Physiology
  • Gladys Jayawardene Gold Medal for Parasitology
  • Daphne Attygalle Medal for Pathology
  • Loos Gold Medal for Pathology
  • NSO Mendis Gold Medal for Pharmacology
  • Vanderstraaten Silver Medal for Hygiene
  • Dr HJ Hazari Medal for 3rd MBBS
  • Herath Gunaratne Prize for 3rd MBBS
  • Mr and Mrs SK Ramaswamy Iyer Scholarship
  • Flora and Wilson Bandaranayake Memorial Book Award
  • Joseph Nalliah Arumugam Memorial Scholarship
  • Dr Alaric Jayasinghe Memorial Gold Medal for Paediatrics
  • The Dudinjishaw Dadabhoy Gold Medal for Medicine
  • Rajasuriya Prize for Clinical Medicine
  • Dr D de S Muthucumarana Memorial Prize for Medicine
  • Professor K Dharmadasa Gold Medal for Clinical Medicine
  • The Sir Andrew Caldecott Gold Medal for Final MBBS
  • The Rockwood Gold Medal for Surgery
  • Dr MVP Pieris Award for Surgery
  • First in order of merit among all medical graduates for 1996 in Sri Lanka.
  • Student of the Year 1996, University of Colombo, Sri Lanka. 

RESEARCH SUPERVISION

  • Viral aetiologies of encephalitis in a hospital-based patient population in Sri Lanka (MPhil)
  • Developing and validating a language assessment tool to diagnose aphasia in a Sri Lankan Sinhala speaking context (PhD)
  • Anticoagulation and antiplatelet therapy and blood pressure control in patients with non-valvular atrial fibrillation
  • Prevalence and EEG patterns of neuro-psychiatric manifestations in systemic lupus erythematosus patients in a tertiary care SLE clinic in Sri Lanka
  • Validation of serum biomarkers for predicting severe dengue-associated disease
  • Predictors of respiratory paralysis and the factors affecting outcome in patients with Guillain-Barre Syndrome
  • Validity of cerebrospinal fluid adenosine deaminase levels as a screening tool in diagnosing tuberculous meningitis in Sri Lankan patients
  • Neurological complications of chronic kidney disease
  • Blood haemoglobin concentration and outcome of ischaemic stroke 

TEACHING EXPERIENCE

Undergraduate and postgraduate Medicine and Neurology

PUBLICATIONS

Books / chapters / e-learning resources

  1. Thashi Chang, Michele Hu. Stiff person syndrome. ebrain, a web-based training resource in clinical neurosciences which is a collaborative project of the Joint Neurosciences Council, the European Federation of Neurological Societies, the European Neurological Society, and University College London. http://www.elearningdigital.com/will/Stiff_Person_Syndrome/index.html
  2. Thashi Chang. A good death. In: Goonaratna C, Balasuriya A, eds. Medicine in the elderly. Volume 2. (in press)
  3. Inoshi Atukorala, Thashi Chang. Musculoskeletal diseases. In: Farrar J, Hotez PJ, Junghanss T, Lalloo DG, White NJ, eds. Manson’s tropical diseases. 23rd edition. Elsevier, 2012. (in press)
  4. Thashi Chang. A case-based guide to stroke and TIA, 2012. ISBN: 978-955-9386-25-4.

Journals 

  1. Wanigasinghe J, Chang T, Vincent A. Treatment responsive, reversible, autoimmune encephalitis in a child. Ceylon Medical Journal 2012;57:90-91
  2. Rathnapala A, Arulenthiran R, Sirimanne G, Chang T. Acquired cutis laxa: an unusual skin manifestation of systemic amyloidosis. Galle Medical Journal 2012;17:50-52.
  3. Chang T, Riffsy MTM, Gunaratne PS. Hashimoto encephalopathy: clinical and MRI improvement following high-dose corticosteroid therapy. The Neurologist 2010;16:394–396
  4. Waidysekara RWHJP, Gunaratne PS, Chang T. An unusual case of treatment responsive limbic encephalitis. Journal of Ceylon College of Physicians 2010;41:32-34.
  5. Chang T. Selected aspects of generalised myasthenia gravis. Journal of the College of Ophthalmologists of Sri Lanka 2009;15(2):59 – 60.
  6. Chang T. TIA revisited. Leading article, Journal of the Ruhunu Clinical Society 2009, 16, 3 - 5.
  7. Chang T, Gunaratne P, Gamage R, Riffsy MT, Vincent A. MuSK-antibody-positive myasthenia gravis in a South Asian population. Journal of Neurological Sciences 2009;284:33-5.
  8. Antozzi C, Frassoni C, Vincent A, Regondi MC, Andreetta F, Bernasconi P, Ciano C,  Chang T, Cornelio F, Spreafico R, Mantegazza R. Sequential antibodies to potassium channels and glutamic acid decarboxylase in neuromyotonia. Neurology 2005;64;1290-1293.
  9. Chang T, Lang B. GAD antibodies in stiff-person syndrome. Neurology 2004;63(11):1999.
  10. Chang T, Ranawaka UK, Gunasekara H, Wijesekera JC. A case of primary neuroleptospirosis. Ceylon Medical Journal 2003;48:143-4.
  11. Ranawaka UK, Chang T, Wijesekera JC. Young patients with movement disorders. Ceylon Medical Journal 2003;48:142-3.
  12. Ariaratnam CA, Chang T, Jayasinghe KSA, Sheriff R. Bilateral cortical necrosis following Hump nosed viper bite. Journal of Ceylon College of Physicians 2001;34:35.
  13. Chang T, Jayasinghe S, Rajapakse S, Sheriff MHR. A patient presenting with features of progressive multifocal leucoencephalopathy in HIV/AIDS.  Ceylon Medical Journal 2001;46:153-4.
  14. Constantine GR, Herath JIP, Chang T, Suganthan P, Thenabadu PN. Management of acute myocardial infarction in the general medical wards. Postgraduate Medical Journal 1999;75:718-20.
  15. Chang T, de Abrew K, Fernando DJS. An audit on structure, process and outcome of care of the diabetic clinic, National Hospital of Sri Lanka. Ceylon Medical Journal 1997;42:133-6.
  16. Chang T, de Abrew K, Fernando DJS, Sheriff R. An evaluation of knowledge about diabetes among final year medical students, non-specialist hospital doctors and general practitioners. Ceylon Medical Journal 1997;43:51-2.

Abstracts 

  1. Chang T, Ibrahim S, Arambepola C. Knowledge of Stroke, stroke warning symptoms, stroke risk factors antiplatelet therapy and stroke units amongst General Practitioners in Sri Lanka. Abstract, Annual Academic Sessions of the Sri Lanka Medical Association, Colombo, 03 – 06 July 2012.
  2. Chang T, Ibrahim S, Arambepola C, Ranasinghe HM, Mihirini AHTM, Weerasinghe D, Vithanage TDP, Maithripala C. Public awareness of stroke, its warning symptoms, risk factors and treatment in Sri Lanka. Abstract, Annual Academic Sessions of the Sri Lanka Medical Association, Colombo, 03 – 06 July 2012.
  3. Chang T, Gajasinghe S, Arambepola C. Epidemiology of stroke in the district of Colombo, Sri Lanka: a community-based study. Abstract, Annual Academic Sessions of the Sri Lanka Medical Association, Colombo, 03 – 06 July 2012.
  4. Malavige GN, Gomes L, Fernando S, Chang T, Alles L, Jayasekera C, Guruge D, Jayaratne SD, Ogg GS. Association of serum IL-10 with severe clinical disease in acute dengue infections. Annual Academic Sessions of the Sri Lanka Medical Association, Colombo, 03 – 06 July 2012
  5. PCI Wijesinghe, M Selvarajah, DS Wijesundara, S Ranawaka, Chang T. Knowledge, attitudes and size of the carbon footprint among Colombo medical students. Annual Academic Sessions of the Sri Lanka Medical Association, Colombo, 03 – 06 July 2012
  6. Chang T, Ibrahim S, Arambepola C. Knowledge of Stroke, stroke warning symptoms, stroke risk factors antiplatelet therapy and stroke units amongst General Practitioners in Sri Lanka. Abstract, 20th World Congress of Neurology, Marrakesh, Morocco, 12 – 17 November 2011.
  7. Chang T, Ibrahim S, Arambepola C, Ranasinghe HM, Mihirini AHTM, Weerasinghe D, Vithanage TDP, Maithripala C. Public awareness of stroke, its warning symptoms, risk factors and treatment in Sri Lanka. Abstract, 20th World Congress of Neurology, Marrakesh, Morocco, 12 – 17 November 2011.
  8. Chang T, Gajasinghe S, Arambepola C. Epidemiology of stroke in the district of Colombo, Sri Lanka: a community-based study. Abstract, Asia Pacific Stroke Conference 2011, 29 September – 01 October, Colombo, Sri Lanka.
  9. Chang T, Leite MI, Senanayake S, Gunaratne PS, Gamage R, Riffsy MTM, Jacobson LW, Vincent A. Clinical and serological study of myasthenia gravis in a South Asian population using both radioimmunoprecipitation and cell-based assays. Abstract, 19th World Congress of Neurology, 24 – 30 October 2009. Journal of the Neurological Sciences 2009; 285(Supplement 1): S152
  10. Chang T, Pettingill P, Alexopoulos H, Jacobson L, Brown P, Vincent A. Autoantibodies to GAD and cell surface determinants in stiff person syndrome. Abstract, 61st Annual Meeting of the American Academy of Neurology, April 25 – May 2, 2009, Seattle, WA, USA.
  11. Thashi Chang, Sunethra Senanayake, Padma S Gunaratne, Ranjanie Gamage, MTM Riffsy and Angela Vincent. Clinical and serological study of myasthenia gravis in Sri Lankan patients. Abstract, Annual sessions of the Association of Sri Lankan Neurologists, November 2008, Colombo, Sri Lanka.
  12. Chang T, Lang B, Brown P, Vincent A. Pathogenicity of autoantibodies in stiff-person syndrome. Abstract, 18th Meeting of the European Neurological Society, Nice, France, 07-11 June 2008. Journal of Neurology 2008;255:(supplement 2) ll/54.
  13. Chang T, Brown P, Vincent A. Autoantibodies in stiff-person syndrome. Abstract, 16th Meeting of the European Neurological Society, Lausanne, Switzerland, 27-31 May 2006. Journal of Neurology2006;253:(supplement 2) ll/32.
  14. Raman A, Khan SA, Jaiser S, Chang T, Chaudhri Q, Vincent A, Bajaj N. A case of anti-GAD positive encephalomyelitis with rigidity occurring in a patient with recently treated nasopharyngeal carcinoma. Abstract, 16th Meeting of the European Neurological Society, Lausanne, Switzerland, 27-31 May 2006. Journal of Neurology 2006;253:(supplement 2) ll/61.
  15. Chang T, Brown P, Vincent A. Characterisation of GAD antibodies in the stiff-person syndrome. Abstract, Association of British Neurologists spring meeting, Brighton, UK, 2006
  16. Chang T. Delayed neurological pathology following severe acute poisoning by organophosphorus pesticides. Abstract, 13th Oxford Tropical Network Meeting, Oxford, UK, 2006.
  17. Chang T, Brown P, Vincent A. Characterisation of GAD antibodies in the stiff-person syndrome. Abstract, Clinical Scientists in Training Meeting, Medical Research Society, London, UK, 2006
  18. Chang T, Vincent A. Characterisation of GAD antibodies in neurological disease. Abstract, 7thInternational Congress of Neuroimmunology, Venice, Italy, 2004. Journal of Neuroimmunology2004;154:196