Name: S. S. S. B. D. Preethi Soysa

Official Address: Department of Biochemistry and Molecular Biology, Faculty   of Medicine Colombo, Sri Lanka

email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Contact No.    94-011-2697485 (official)

Educational qualifications:

  • B.Sc in Applied Sciences (1979), University of Sri Jayawardenapura, Sri Lanka
  • M.Sc in Biochemistry (1982), University of Colombo, Sri Lanka
  • Ph. D in Biochemistry (1996), University of Colombo, Sri Lanka

 Field of Study for Ph.D

  • Drug Disposition and Interactions

 

PROFESIONAL EXPERIENCE

Undergraduate Research Supervision

  • Departments of Chemistry and Plant Sciences, University of Colombo
  • Department of Botany, University of Sri Jayawardenapura
  • Institute of Chemistry, Sri Lanka
  • MBBS, Faculty of Medicine Colombo

Postgraduate Teaching

  • M.Sc in Molecular Biology and Biochemistry, Faculty of Medicine, Colombo.
  • M.Sc in Molecular Medicine, Postgraduate Institute of Medicine, Colombo
  • M.Sc in Environmental Science, Open University of Sri Lanka

POSTGRADUATE RESEARCH SUPERVISION

Ph.D University of Colombo

Ms. Dilusha Fernando, Co-supervisor

  • Investigation of metabolites of macrofungi against cancer related targets; modulation of apoptosis and isolation of active compounds


Mr. Amal Wageesha

  • Anticancer activity of a selected traditional drug formulation

Mr. Dananjaya Perera (Ongoing)

  • Hepatoprotective Activity of Phyllanthus debilis Klein ex Willd (Elapitawakka) plant

Ms. Bhagya Deepachandi, Co-supervisor, (Ongoing)

  • Study of Immuological Characteristic of Leishmaniasis in Sri Lanka

M.Phil dgree, University of Colombo, Sri Lanka

Cytotoxicity studies with different extracts of Pleurotus Cystidiosnus.- Enoka Manikpurage (2006/2007), Co-supervisor

Anti cancer activity of tea products manufactured in Sri Lanka- Ms Subashini Adikary

M.Phil.

Co-investigator

Paracetamol Analysis- The economical burden of current management of patients with acute

paracetamol poisoning in tertiary care hospital of Sri Lanka- Ganga Senaratne (2006)

 Ongoing/Completed Research

Studies on

  • Abnormal Urinary metabolites in Autism Children
  • Cytotoxicity and Apoptosis Studies with Tea, Herbal Teas and Aurvedic Drug Preparations and plants,
  • Iron absorption in Different Rice Varieties
  • Antioxidant activity of plants and biological fluids
  • Metabolism of Tea Polyphenols,
  • Drug interactions with Food/Herbs using liver slices
  • Pharmcokinetic analysis of drugs
  • Paracetamol levels in blood under different setups

 Postgraduate research supervision

M.Sc in Biochemistry and Molecular Biology, Dept of Biochemistry and Molecular Biology, Faculty of Medicine, Colombo      

  • Studies on anticancer activity of `Triphala’: Nirmani Yasara (2016)
  • Studies on hepatoprotective activity `Kokmota’ using liver cell line J.H.A.C.P. Jayathilake (2016)
  • Pomegranate effect of breast cancer cells- at molecular level W.A.C.L. Jayasekara (2016) (Cosupervisor)
  • Antioxidant Activity, Cytotoxicity and Induction of Apoptosis by Three Selected Medicinal Plants RA Udeshika Imali Ranatunge (2014)
  • Evaluation the efficacy of folic acid, folate and polyphenol free extracts on reducing intracellular homocysteine utilizing porcine live slices as an In Vitro Model. Mr Rajendra Joseph Handagama (Cosupervisor) (2014)
  • Screening of camptothecin levels and studies on antioxidant and anticancer activity of ophiorrhiza mungos plant. Shaneeka Kanchanee Weerasinghe (2014)
  • Antioxidant activities of aqueous extracts of Atalantia ceylanica and Eriocaulon sp. Linn and their hepatoprotective activity against drug induced liver toxicity using porcine liver slices S.C.D.Fernando (2012)
  • Effects of herbal plant extracts on Paracetamol metabolism and liver toxicity using porcine liver slices (2012)
  • Evaluation of phytochemical composition, antioxidant activity and anticancer activity of Semecarpus parvifolia leaf extracts- DDPP Jayarathna (2012)
  • Effects of ayurvedic herbal decoction “pas panguwa” on Paracetamol pharmacokinetics (2010)
  • Apoptosis studies with  Flueggea leucopyrus (2010) Irushi de Silva
  • Apoptosis studies A decoction composed of Adenanthera pavonina L. and Thespesia populnea L.(2010) Kalhari Silva
  • Analysis of children with autism and laearning difficulties:Optimization of polymerase chain reaction of CYP271B1 gene and analysis of urinary metabolites of purine metabolism and sulphoconjugation (2010) MKAN Wijemanne
  • Apoptosis studies with a selected decoction used in cancer therapy  – Priyantha Ihalagamage (2008)
  • Apoptosis studies with tea constituents (2005) - Subashini Jayawardena
  • Preliminary Studies on absorption and elimination of Tea Polyphenols in Rats (2000) - WAIC Silva

 M.Sc in Analytical Chemistry, Faculty of Science, University of Colombo

  • Apoptosis studies with herbal extracts - Namal Perera (2006)

M.Sc in Clinical Biochemistry, Postgraduate Institute of Science, Peradeniya

         Screening of Camptothecin in plants belong to Family Rubiaceae-Jayaraj J Thusyanathan (2012)

 M.Phil dgree, University of Colombo, Sri Lanka

  • Biological activities of selected fungi
  • Anti cancer activity of selected medicinal plants  in Sri Lanka
  • Cytotoxicity studies with Different extract of Pleurotus Cystidiosnus.- Enoka Manikpurage (2006/2007)
  • Anti cancer activity of tea products manufactured  in Sri Lanka
  • Paracetamol Analysis- The economical burden of current management of patients with acute paracetamol poisoning in tertiary care hospital of Sri Lanka- Ganga Senaratne (2006)

 M.Sc. in Food Science, Faculty of Applied Sciences, University of    Sri Jayawaredanapura, Nugegoda, Sri Lanka

Co-supervisor

  • Estimation of Vitamin A levels in Milk During Storage  -  MW Galahitiyawa

 MD Institute of Indigenous Medicine, University of Colombo

Co-supervisor

A comparative clinical evaluation of vasaguduchyadi decoction and aniththadi lepa with and without virechana karma with weliwenna in the management of kitibha (psoriasis) Dr Anura Devanarayana 2016.

 

RESEARCH GRANT AWARDED


Principal investigator

Induction of Apoptosis by tea and metabolism of tea polyphenolsNational Research Council, Sri Lanka (2000),

Induction of Apoptosis in cell lines by selected traditional medicine. National Science Foundation Sri Lanka, (2006),

The effect of tea infusion (Camellia Sinensis) on metabolism of acetaminophen in humans IRQUE project Sri Lanka (2006),

Induction of Apoptosis in cell lines by a traditional drug `Le pana Guliya ’University of Colombo (2012)

Studies on Hepatoprotective activity of a selected herb using a liver cell line. University of Colombo (2014)

Co-investigator

1. Study of Immunological characteristic of Leishmaniosis in Sri Lanka University of Colombo (Co investigator) University of Colombo 2014

2. Proliferative and toxicological effects of selected herbs on in-house established mesenchymal stem cells (Co investigator) NSF 2015

3. Anti- dengue viral activity in a selected number of plants used in Sri Lankan traditional medicine, University of Sri Jayawardenapura (2017)

LABORATORY PLANNING AND DEVELOPMENT

1. Establishment of a laboratory for stem cell research

2. Establishment of an animal cell culture laboratory

3. Therapeutic drug analysis

POSTS HELD IN SCIENTIFIC ORIGINATIONS

President of the Section E2 of Sri Lanka Association for Advancement of Science., 2013

Vice President Section E2 of Sri Lanka Association for Advancement of Science.

Vice President Environment Committee, Sri Lanka Association for Advancement of Science 2015

Committee member

E2 of the Sri Lanka Association for Advancement of Science 2012 and 2014

Environment Committee 2012-2015

MEMBERSHIP OF PROFESSIONAL ASSOCIATIONS

Institute of Biology (Life Member)

Sri Lanka Association for Advancement of Science (Life Member)

SERVICES

Therapeutic drug Analysis of Antiepileptic drugs, Paracetamol, Salicylate, Theophylline

PATENTS

International patent ( PCT/IB2015/059027). Title- A novel method to isolate inoscavin A from Fulviformes fastuosus and medicinal preparation thereof to treat rhabdomyosarcoma cancer conditions. Co-investigator

AWARDS


1. Second Place "Antiproliferative activity and induction of apoptosis by a decoction prepared from Adenanthera pavonina and Thespesia populnea" "International Conference on Stem Cells and Cancer (ICSCC-2010): Proliferation, Differentiation and Apoptosis", 11-14 December,2010 Pune, India. Authors: L.I.K Silva and S.S.S.B.D.P. Soysa,

2. Merit Award for 2013, National Research Council, Sri Lanka.

3. President’s Award for Research, National Research Council, Sri Lanka. 2014 (awarded in 2016)

4. Professor M.U.S. Sultanbawa Award for Research in Chemistry – 2015 for the best research paper presented at the Annual Sessions of the Institute of Chemistry Ceylon in June 2014. Co-Author In-vitro radical scavenging properties, anti-inflammatory and α-amylase inhibitory activities of Eriocaulon quinquangulare aqueous extract. Fernando S.C.D. & Soysa S.S.S.B.D.P.

5. Kandiah Memorial Graduateship Award - 2015 awarded to Dilanka Fernando for the best piece of research in the Chemical Sciences carried out by a Graduate Chemist of the Institute Chemistry Ceylon registered with a Higher Educational Institute for a postgraduate Degree. Co-Author, Fernando S.C.D. & Soysa S.S.S.B.D.P., Title: Time course variation of nutraceuticals and antioxidant activity during steeping of CTC black tea (Camellia sinensis L.) manufactured in Sri Lanka.

6. Postgraduate Research Award 2015 First Place A study on seroprevalence of cutaneous leishmaniasis in Sri Lanka using a locally developed enzyme-linked immunosorbent assay. Co Author. M.A.B. Deepachandi, N. Ali, S.S.S.B.D.P. Soysa, N.D. Karunaweera,and H.V.Y.D. Siriwardana,


7. Postgraduate Research Award 2016, Second Place (Poster Presentation) Co-Author, Comparative Study of Nauclea orientalis L., Clerodendrum infortunatum L.and Paramignya monophylla on their Anti-oxidative Potential and Apoptosis Induction. Imali Ranathunge and Preethi Soysa

8. President’s Award for Research (2015), National Research Council, Sri Lanka.

9. Best Presentation 2017, Co-author Anticancer activity and antiproliferative activity of Triphala. KDU International Research Conference Nirmani Yasara and Preethi Soysa NATIONAL AND INTERNATIONAL RESEARCH COLLABORATION Professor Iqbal Choudhary, HEJ Institute, Pakistan. Iron bioavailability in locally grown rice ITI, Sri Lanka, (2011)

NATIONAL AND INTERNATIONAL RESEARCH COLLABORATION

Professor Iqbal Choudhary, HEJ Institute, Pakistan.

Iron bioavailability in locally grown rice ITI, Sri Lanka, (2011)

International Fellowships/Awards

 Fellowship under Scientist Exchange Programme by Science and Technology Agency, Japan (1996)

 Silver medal - L.I.K Silva  and S.S.S.B.D.P. Soysa,  "Antiproliferative activity and induction of apoptosis by a decoction prepared from Adenanthera pavonina and Thespesia populnea"  "International Conference on Stem Cells and Cancer (ICSCC-2010): Proliferation, Differentiation and Apoptosis", 11-14 December,2010 Pune, India.

 Research Publications

1. Imali Ranathunge,Subashini Adikary,Piumi Dasanayake,Chamira Dilanka Fernando and Preethi Soysa''Development of a rapid and simple method to remove polyphenols from plant extracts'' International Journal of Analytical Chemistry 2017.   

2. N.D.A Wageesha,Preethi Soysa,Keerthi Atthanayake,Muhammad Iqbal Choudhary,Mahinda Ekanayake Evaluation of antioxidant and polyphenolic content of a Sri Lankan poly herbal formulae and assessment of its in vitro antiproliferative activity on RD and MCF-7 cancer cells compared to healthy CCI cells.Cancer Studies
and Therapeutics.Volume 2(3),2017.

3.N.D.A Wageesha,Preethi Soysa,Keerthi Atthanayake,Muhammad Iqbal Choudhary,Mahinda Ekanayake.A traditional poly herbal medicine 'Le Pana Guliya'' induces apoptosis in HepG2 and Hela cells but not in CCI cells:an in vtro assesment.2017.DOI:10.1186/s13065-016-0234-4CCJO-D-16-00207.1.

4.Dilusha Maduranganie Fernando,Achyut Adhikari,Chandrika Nanayakkara,Dilip de Silva,Ravi Wijesundar,Preethi Soysa,Isolation of Ergone,a potent anticancer agent from terrestrial mushroom Fulviformes fastuosus.BMC Complementary and Alternative Medicine 2016.

5.Piumi Dasanayake and Preethi Soysa,Distribution of phenolic content and screening for antioxidant capacity of different parts of tea plant (Camellia sinensis L).Journal of Medicinal plants Research Vol.10(33),570-574,September 2016 DOI:10.5897/JMPR2016.6212.

6.Dananjaya Perera;Preethi Soysa;Sumedha Wijeratne'Polyphenols contribute to the antioxidant and antiproliferative activity of phyllanthus debilis plant in-vitro' BMC Complementary and Alternative Medicine.2016,16:339 DOI:10.1186/s12906-016-1324-5.

7.Katuwavila,A.D.L.Chandani Perera,Sammera R.Samarakoon,Preethi Soysa,Veranja Karunaratne,Gehan A.J.Amaratunga,and D.Nedra Karunaratne''Chitosan-alginate nanoparticle system efficiently delivers doxorubicin to MCF-7 cells'' Volume 2016(2016),Article ID 3178904,12pages.doi:10.1155/2016/3178904.

8.CD Fernando,P Soysa simple isocratic method for simultaneous determination of cafferine and catechins in tea products by HPLKC Springerplus 5(1),1-5,2016.

9.Chamira Dilanka Fernando,Preethi Soysa.Evaluation of Hepatoprotective activity of Eriocaulon quinquangulare in vitro using porcine liver slices against ethanol induced liver toxicity and free radical scavenging capacity BMC Complementary and Alternative Medicine DOI:10.1186/s12906-016-1044-x 2016

10.Indeewari Kalhari Silva Lindamulage,Preethi Soysa Evaluation of anticancer properties of a decoction containing Adenanthera pavonina L.and Thespesia populnea L.BMC complementary and alternative medicine 16 (1), 1 2016.

11.Dilusha M Fernando,Ravi LC Wijesundara,Preethi Soysa,Chandrika M Nanayakkara and Dilip de Silva Antioxidant activity and in vitro cytotoxicity of the terrestrial Basiodiomycete,Anthracophyllum lateritium BMC Complementary and Alternative Meicine(2015)15:398DOI 10.1186/s12906-015-0924-9.

12.Devanarayana A,Ediriweera Soysa S.S.S.B.D.P Therpeutic usage of rhinacanthus nasutus (L)Kurz(Aniththa)in Sri Lanka Traditional Medicine Unique Journal of Ayurvedic and Herbal Medicines,03(04):page 10-15,2015.

13.Dilusha Fernando,Ravi Wijesundera,Preethi Soysa,Dilip de Silva,Chandrika Nanayakkara.Strong Radical Scavenging Macrofungi from the Dry Zone Forest Reserves in Sri Lanka.Frontiers in Environment Microbiology.Vol1,(2),2015,32-38.doi:10.11648/j.fem.20150102.15.

14.Fernando S.C.D & Soysa S.S.S.B.D.P.,In-vitro radical scavenging properties,anti inflammatory and α-amylase inhibitory activities of Eriocaulon quinquangulare acqueous extract,Chemistry in Sri Lanka,Vol.32(2),16-33,2015.

15.Fernando S.C.D.& Soysa S.S.S.B.D.P.,Time Course Variation of Nutraceuticals and antioxidant activity during steeping of CTC Black Tea(Camellia Sinensis L) manufactured in Sri Lanka.Chemistry in SriLanka,,Vol.32,No.3,34-40,2015.

16. Chamira D. Fernando and Preethi Soysa. Extraction Kinetics of phytochemicals and antioxidant activity during black tea (Camellia sinensis L.) brewing. Nutrition Journal (2015) 14:74 DOI 10.1186/s12937-015-0060-x.

17. Chamira Dilanka Fernando, Preethi Soysa. Optimized enzymatic colorimetric assay for determination of hydrogenperoxide (H2O2) scavenging activity of plant extracts MethodsX 2(2015)283–291. http://dx.doi.org/10.1016/j.mex.2015.05.001.

18. Fernando, M.D.M., Wijesundera R.L.C., Soysa S.S.B.D.P., de Silva E.D., Nanayakkara C.M., (2014)"Antioxidant activity, total phenol and flavonoid contents of the white rot macrofungi Flavodon flavus (Klotzsch.) and Xylaria feejeensis (Berk.)"JBSR.

19. Chamira D Fernando and Preethi Soysa. Total phenolic flavonoid contents in-vitro antioxidant activities and hepatoprotective effect of aqueous leaf extract of Atalantia ceylanica. BMC Complementary and Alternative Medicine, 2014, 14:395 doi:10.1186/1472-6882-14-395p 29-44.

20. Soysa P, De Silva IS, Wijayabandara J.Evaluation of antioxidant and anti proliferative activity of Flueggea leucopyrus Willd (katupila). BMC Complement Altern Med. 2014 Jul 30;14(1):274. doi:10.1186/1472-6882-14-274.

21. M.D.K. Ganga Senarathna, Shalini S. Ranganathan, Nick Buckley, S.S.S.B.D. Preethi Soysa, B.M. Rohini Fernandopulle. A quick inexpensive laboratory method in acute paracetamol poisoning could improve risk assessment, management and resource utilization. Indian Journal of Pharmacology 2012;44 (4): 463-468.

22. A.D.C.S. Rupasinha, W. Pathirana, C. Weeraratne, S. S. S. B. D. P. Soysa, N. KulathungaDrug levels in isolated chylomicrons as a determinant tool of the hepatic bypass absorption pathway.The International journal of pharmaceutical science 2011, vol. 6, issue 2, July-December’, p24-33.

23. Chamira D Fernando and Preethi Soysa. Total phenolic flavonoid contents in-vitro antioxidant activities and hepatoprotective effect of aqueous leaf extract of Atalantia ceylanica. BMC Complementary and Alternative Medicine 2014, 14:395 doi:10.1186/1472-6882-14-395p 29-44.

24. Soysa P, De Silva IS, Wijayabandara J.Evaluation of antioxidant and anti proliferative activity of Flueggea leucopyrus Willd (katupila). BMC Complement Altern Med. 2014 Jul 30;14(1):274. doi:10.1186/1472-6882-14-274

25.S.M.D.K. Ganga Senarathna, Shalini S. Ranganathan, Nick Buckley, S.S.S.B.D. Preethi Soysa, B. M. Rohini Fernandopulle. A quick inexpensive laboratory method in acute paracetamol poisoning could improve risk assessment, management and resource utilization. Indian Journal of Pharmacology 2012;44 (4): 463-468.

26.Inoka P. Menikpurage, S.S.S.B.D.P. Soysa, D.T.U. Abeytunga, Antioxidant activity and cytotoxicity of the edible mushroom, Pleurotus cystidiosus against Hep-2 carcinoma cells J.Natn.Sci.Foundation Sri Lanka 2012 40(2):13-20

27.Indeewari Kalhari Silva and Preethi Soysa,  Evaluation of  Phytochemical Composition and Antioxidant Capacity of A Decoction Containing Adenanthera pavonina. L and Thespesia Pharmacogn Mag. 2011 Jul-Sep; 7(27): 193–199.

28.Soysa Preethi and Kolombage Saman Rapid HPLC/UV method for analysis of urinary and plasma/serum paracetamol concentrations  J.Natn.Sci.Foundation Sri Lanka 2010 38 (2):131-137

29.M.G.A.N.Perera, S.S.S.B.D.P Soysa, D.T.U Abeytunga, R Ramesh  (2008), Antioxidant cytotoxic properties of three traditional decoctions used for the treatment of cancer in Sri Lanka.  Pharmacognosy Magazine Vol 4, 172-181.

 Communications with Published Abstracts

1. J.W.N.Yasara, Preethi Soysa, Cytotoxicity and apoptosis inducing ability of Triphala. University of Colombo, Annual Research Symposium 2017.

2. Jayathilake J.H.A.C.P. and Soysa S.S.S.B.D.P.. Hepatoprotective activity of Atalantia ceylanica against ethanol induced hepatotoxicity on HepG2 human liver cells. University of Colombo, Annual Research Symposium 2017.

3. M. A. B. Deepachandi, S. Weerasinghe, N. H. Silva, S. Senanayake, T.N. Samaranayake, S. S. S.B. D. P. Soysa, N. D. Karunaweera, H. V. Y. D. Siriwardana. Need for Continued Awareness
Raising on Cutaneous Leishmaniasis in Sri Lanka: A Case Series. University of Colombo, Annual Research Symposium 2017.

4. Chathurika Lakmali Jayasekara, Chamindri Witharana1 Preethi Soysa Cells University of Colombo, Annual Research Symposium 2017.

5. V. L. Udalamaththa, P. M. S. Ratnayake, P Soysa, S. Wijeratne, P. V. Udagama. Effect of Sri Lankan wild type Mature Leaf Concentrate of Carica Papaya on adipogenic
differentiation of in house established human Mesenchymal Stem Cells University of Colombo, Annual Research Symposium 2017.

6. V. L. Udalamaththa, P. M. S. Ratnayake, P Soysa, S. Wijeratne, P. V. Udagama. Effect of Mature leaf concentrate of Carica papaya and Ficus benghalensis leaflet distillate on chondrogenic differentiation of human mesenchymal stem cells. 5th international conference of ayurveda , unani, siddha and traditional medicine"

7. R.A.U.I Ranatunge, Preethi Soysa. Induction of Apoptosis in Hepatocellular Carcinoma (HepG2) and Rhabdomyosarcoma (RD) Cells by Fresh Leaves of Camellia sinensis Grown in Selected Areas of Uva Province, Sri Lanka. Annual Research Symposium, University of Colombo. November, 2017, Colombo, Sri Lanka.

8. Katuwawala A, Gooneratne LV, Soysa , S.S.S.B.D.P, Kottahachchi D. U, .Jayasekera G.A. U Analysis of protein profiles of plasma cells in patients with multiple myeloma.Annual Research Symposium, University of Colombo. November, 2017, Colombo, Sri Lanka.

9. Udeshika Yapa Bandara, Chamindri Witharana, Preethi Sosa. Total Phenolic Content from Pomegranate Fruit by Different Extraction Methods. International Conference onCurrent Trends of Traditional Herbal Medicine, Singapore, SG during January, 8-9, 2018

10. Yasara N, Soysa P. Anticancer activity and antiproliferative activity of Triphala. KDU International Research Conference – 2017

11. Perera D, Preethi Soysa, Sumeda Wijerathne Optimization of parameters and development of cost effective method for isolation and propagation of Umbilical cord blood derived Mesenchymal stem cells. KDU International Research Conference – 2017

12. Wageesha N.D.A, P, Soysa, AAP Keerthi, I Choudhary and M Ekanayake (2017).Traditional anti cancer drug “Le Pana Guliya” induced oxidative stress via depletion of Reduced Glutathione; An in vitro assessment. 4th Hamdard International conference on Unani medicine 2017, Karachi, Pakistan.

13. Wageesha N.D.A, P, Soysa, AAP Keerthi, I Choudhary and M Ekanayake (2017).Evaluation of anti proliferative activity and mechanism of action of a polyherbal drug formulation used in traditional medicine for cancer therapy. 7th International Conference on Ayurveda, Homeopathy and Chinese Medicine, Munich Germany.

14. Wageesha N.D.A, P, Soysa , AAP Keerthi, I Choudhary and M Ekanayake (2017).Evaluation of antiproliferative activity of a polyherbal drug formulation used in traditional medicine for cancer therapy. 10th Annual World Cancer Congress (WCC-2017), Barcelona,Spain.

15. Wageesha N.D.A, P, Soysa, AAP, Keerthi, I, Choudhary and M, Ekanayake (2017).Evaluation of antioxidant and polyphenolic content of a Sri Lankan poly herbal formulae and assessment of its in vitro antiproliferative activity and mechanism of action on RD and MCF-7 cancer cells compared to healthy CC1 cells. 3rd International Conference and Expoon Herbal and Alternative Medicine, London, United Kingdom.

16. Perera D, Preethi Soysa, Sumeda Wijerathne. Phyllanthus debilis Klein ex Willd root extract induces apoptosis mediated cell death in cultured RD cells. 72nd Annual Scientific Session 2016 Sri Lanka Association for the Advancement of science.

17. Wijayabandara M.D.J, Mendis B.M.M.J , Wijayabandara M.D.L.O Iqbal Choudhary M,Soysa S.S.S.B.D, Ahmed Mesaik M, Rahuman Hafizur Characterization of Pharmacological Activity and the Major Active Constituent of Flueggea leucopyrus Willd.14th Euroasia Conference on Chemical Sciences, December 15th-17th . Karachi, Pakistan.

18. S. Vaihunthan , S.S.B.P. Soysa, V.H.W. Dissanayaka, S.M.T. Jayasena. Transfection of HepG2 cells with pmirGLO reporter: optimization of dual luciferase reporter assay. Postgraduate Symposium, Faculty of Medicine, Colombo 2016

19. R.A.U.I Ranatunge, Preethi Soysa. Comparative Study of Nauclea orientalis L,Clerodendrum infortunatum L. andParamignya monophylla on their Anti-oxidative Potential and Apoptosis Induction Postgraduate Symposium, Faculty of Medicine,Colombo 2016

20. M. A. B. Deepachandi, K. K. G. D. U. L. Kariyawasam, S. Weerasinghe, C. Gunasekara,S. S. S. B. D. P. Soysa, N. D. Karunaweera, H. V. Y. D. Siriwardana A Case Report of Cutaneous Leishmaniasis affecting the Nasal Process Faculty Research Symposium'2016

21. Deepachandi MAB, Kariyawasam KKGDUL, Weerasinghe S, Ejazi SA, Ali N, Soysa SSSBDP, Karunaweera ND, Siriwardana HVYD, A serological study on cutaneous leishmaniasis in Sri Lanka reveals antigen heterogeneity, 128th Anniversary International Medical Congress, Sri Lanka Medical Association2015, Abstract (pp109)

22. Kotalawala HS, Kariyawasam KKGDUL, Deepachandi MAB, Weerasinghe S,Siriwardana HVYD, Karunaweera ND, Laboratory diagnosis of cutaneous leishmaniasis:are second line investigations really necessary?, 128th Anniversary International Medical Congress, Sri Lanka Medical Association, 2015, Abstract (pp070)

23. M. A. B. Deepachandi, K. K. G. D. U. L. Kariyawasam, S. Weerasinghe, S. S. S. B. D. P.Soysa, H. V. Y. D. Siriwardana, N. D. Karunaweera, Clinico-Epidemiological Pattern of Cutaneous Leishmaniasis in Sri Lanka, Faculty Research Symposium 2015, Faculty of Medicine, Colombo, Abstract (pp1)

24. M. A. B. Deepachandi, N. Ali, S. S. S. B. D. P. Soysa, N. D. Karunaweera, H. V. Y. D.Siriwardana, A Study on Seroprevalence of Cutaneous Leishmaniasis in Sri Lanka using a Locally Developed Enzyme-Linked Immunosorbent Assay, Faculty Research Symposium 2015, Faculty of Medicine, Colombo, Abstract (op6)- An award for the best oral presentation

25. Imali Udeshika Ranathunga and Preethi Soysa. Investigation of Phytochemical Content, Antioxidant Activity and Antiproliferative Activity of Nauclea orientalis L. and Clerodendrum infortunatumL. Proceedings of the 69th Annual Scientific Sessions of SLASS, 2015

26. Dananjaya Perera, Preethi Soysa and Sumeda Wijerathne Antiproliferative activity of Phyllanthus debilis Klein ex Willd Plant 8thInternational Research Conference of Kotelawala Defence University 27th and 28th August 2015. Page 159

27. Dananjaya Perera, PreethiSoysa, SumedaWijerathne, Investigation of the effects of polyphenols present in Phyllanthusdebilis Klein ex Willd Plant on antioxidant activity and evaluation of cytotoxicity against RD (Rhabdomyosarcoma) cells. 71st Annual Scientific Session 2015 Sri Lanka Association for the Advancement of Science- 30th November 2015 to 4thDecember 2015

28. Perera D, Preethi Soysa, SumedaWijerathne. Study on hepatoprotective activity of Phyllanthus debilis Klein ex Willd (Elapitawakka) plant for ethanol induced toxicity using a liver cell line. National Conference on Indigenous Systems of Medicine (BMARI)-17th and 18th Oct 2015. Page 14

29. Perera D, Preethi Soysa, SumedaWijerathne. Polyphenols are responsible for DPPH radical scavenging activity of Phyllanthus urinaria (Rathu Pitawakka) plant. 3rd International Conference on Ayurveda, Unani, Siddha and Traditional Medicine –ICAUST 2015.

30. Fernando, M.D.M., Wijesundera R.L.C., Soysa S.S.B.D.P., de Silva E.D., Nanayakkara C.M., (2015). In vitro antiproliferative activity of the Sri Lankan mushroom Fulviformes fastuosus.National Conference on Indigenous Systems of Medicine.

31. R.A.U.I Ranatunge, Preethi Soysa. Anti-proliferative Activty and Apoptosis Inducing Effect of Bark Nauclea orientalis L. EMBO Workshop on “Mitochondria, Apoptosis & Cancer” (MAC'15), September 10 - 12, 2015, Frankfurt, Germany.

32. Wageesha, N.D.A, P, Soysa AAP Keerthi, I Choudhary and M Ekanayake.(2015).Intrinsic anti cancer effects of aqueous extract of poly herbal drug named “ Le Pana guliya” on HepG2 and RD cells. 3rd International conference on Ayurveda, Unani, Siddha and Traditional medicine 2015. Institute of Indigenous Medicine, University of Colombo, Rajagiriya, Sri Lanka.

33. Wageesha NDA, P, Soysa AAP Keerthi, I Choudhary and M Ekanayake. Antiproliferative activity of aqueous extract of the “Le Pana Guliya”, A scientific insight.National Conference on Indigenous Systems of Medicine .Research and Innovations in Indigenous Systems of Medicine for 21st Century. Bandaranaike Memorial Ayurvedic Research Institute 2015.

34. NDA Wageesha, P, Soysa AAP Keerthi, I Choudhary and M Ekanayake. Screening of Anti-Cancer Activity of a Poly herbal drug used in traditional medicinal practice. 8th International Research conference (IRC-8). Inculcating Professionalism for National Development. General Sir John Kotelawala Defence University 2015.

35. Fernando S.C.D. & Soysa S.S.S.B.D.P Antioxidant capacity of tea infusion correlates with the phytochemicals extracted during steeping of black tea (Camellia sinensisL.)12th Asian Congress of Nutrition, Yokohama, Japan, 14th– 18thMay, 2015.

36. Dananjaya Perera and Preethi Soysa. Preventive activity of DNA damage and hydroxyl radical scavenging activity of the water extract of Phyllanthus debilis plant 2nd International Conference on Ayurveda, Unani, Siddha & Traditional Medicine (ICAUST 2014 16th- 18th December) Page 147.

37. M.D.M. Fernando R.L.C. Wijesundera, S.S.B.D.P. Soysa, E. Dilip de Silva and C.M. Nanayakkara Correlation of phenol and flavonoid content with the DPPH radical scavenging activity of macrofungi from Minneriya and Sigiriya, 34th Annual Sessions of the Institute of Biology, Sri Lanka.26th September, 2014

38. J. K. K. Buddika Antibacterial activity of Oldenlandia umbellate, , C. D. Wijayarathna and P. Soysa34th Annual Sessions of the Institute of Biology, Sri Lanka.26th September,2014

39. J. Thusyanthan1, P. Soysaand R. Sivakanesan. Antioxidant activity of some selected medicinal plants of family rubiaceae and acanthaceae using 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. Proceedings of the Peradeniya Univ. International Research Sessions, Sri Lanka, Vol. 18, 4th & 5th July, 2014 p363

40. Fernando S.C.D. & Soysa S.S.S.B.D.P., In-vitro radical scavenging properties, antiinflammatory and α-amylase inhibitory activities ofEriocaulon quinquangulare aqueous extract, Chemistry in Sri Lanka, May 2014, Vol. 31, No. 2, pg. 16.

41. S. C. D. Fernando and S. S. S. B. D. P. Soysa. Time course variation of phenolic, flavonoid contents and antioxidant activity during steeping of Sri Lankan CTC black tea (Camellia sinensis)

42. Fernando S. C. D. & Soysa P., Hepatoprotective activity of Atalantia ceylanica and Eriocaulon quinquangulare against ethanol induced liver toxicity studied using porcine liver slice in-vitro model, Proceedings of the 69th Annual Scientific Sessions of SLASS, 2013.


43. Fernando S. C. D. & Soysa P., Simple colorimetric assay for determination of hydrogen peroxide (H2O2) scavenging activity of plant extracts, Proceedings of the 69th Annual Scientific Sessions of SLASS, 2013

44. S. C. Dilanka Fernando* and Preethi Soysa. In-vitro antioxidant activity, flavonoids and total phenolic content of Atalantia ceylanica and Eriocaulon quinquangulare Proceedings of the Annual Sessions Institute of Chemistry, Sri Lanka. 2013,

45. M.D.M.Fernando, R.L.C. Wijesundera, Preethi Soysa, C.M. Nanayakkara, E. Dilip de Silva.Anti-oxidant activity, total phenol and flavonoid content of selected macro fungi from the dry zone of Sri Lanka. Proceedings of the 69th Annual Sessions of Sri Lanka Association for Advancement of Science.2012,

 46.DDPP Jayarathna and SSSBDP Soysa. Total phenolic content and antioxidant activity of the water extract of Semecarpus parvifolia (Heen Badulla). Proceedings of the 68th Annual Sessions of Sri Lanka Association for Advancement of Science.2012, p66.

47.M.K. Nimanthi W. Ekanayake.  Hemamali Perera, S.S.S.B.D. Preethi  Soysa, Sulochana  Wijesundera Abnormal Purine Metabolism in Children with Autism. 35th Australian Association for Cognitive and Behavior Therapy Conference, Gold coast, QLD, Australia,17th-19th  October 2012.

48.Siriwardena HVYD, Ranasinghe GSP, Weerasinghe S, Soysa SSBDP, Karunaweera ND. A study on the visceralization potential of Cutaneous Leishmanaiasis in Sri Lanka. Annual Research Symposium 2012, University of Colombo. 16th and 17th August 2012.

49.Wijayabandara M.D.J, Mendis B.M.M.J, Iqbal Choudhary M, Soysa S.S.S.B.D.P, Ahmed Mesaik M. Characterization of biological activity and the major active constituent of Flueggea leucopyrus Willd. 13th International Congress of the Society for Ethnopharmacology, September 2-6, 2012,Graz, Austria

50.Prasanna N,Goonaratne LV , BCM Wimalachandra, HMJP Herath, MD Perera, DP Suriyamudalige, KSJ Kolambage, SSBDP Soysa, PC Rodrigo, S Rajapakse. Aspirin resistance among Sri Lankan patients,Scientific Sessions MRI RESEARCH DAY 2012

51.N Prasanna, LV Goonaratne, BCM Wimalachandra, HMJP Herath, MD Perera, DP Suriyamudalige, KSJ Kolambage, SSBDP Soysa, PC Rodrigo, S Rajapakse. Aspirin resistance among Sri Lankan patients; Sri Lanka Medical Association 125th Anniversary International Medical Congress, 2 to 6 July 2012

52.M. K. Nimanthi W. Ekanayake, S. S. S. B. D. Preethi Soysa, Hemamali Perera. Analysis of sulphoconjugation in children with autism and learning difficulties 12th International Child Neurology Congress and 11th Asian and Oceanian Congress of Child Neurology. May 27th-1st June 2012.

53.M.G.P Dassanayake, S.S.S.B.D.P Soysa and P.L Hettiarachhi Antioxidnat activity and the distribution of phenolic compounds in different parts of the tea plant (Camellia sinensis L). International Conference on Chemical Sciences Colombo, Sri Lanka June 19th -24th 2012

54.Irushi De Silva, Preethi Soysa and Jayantha Wijayabandara. Cytotoxic activity of the aqueous extract of Fluggea leucopyrus  (Katupila) leaves against HEp-2 cells. 3rd International Conference on Medicinal Plants and Herbal Products 2011 Sri  Lanka p 106-107.

55.Preethi Soysa, Tharaka Bandara, Randeevari Gunarathne, Priyanga Ranasinghe, Sashimali Wickramasinghe. 'Effect of tea constituents on paracetamol pharmacokinetics in healthy volunteers'  Asian Federation for Pharmaceutical Science Conference 2011. Kuala Lampur Malaysia

56.MK Nimanthi W Ekanayake, SSBDP Soysa Development and Validation of High Performance Liquid Chromatography/ UV Method for Simultaneous Determination of Urinary Uric Acid, Hypoxanthine and Creatinine. Pittcon Conference and Expo 2011 Atlanta

57.Hemamali Perera, Preethi Soysa, Sulochana Wijesundera, Nimanthi Wijemanne. Analysis of Urinary Purine Metabolites in Children with  Autism. Sri Lanka College of Psychiatrists. Annual Academic Conference, Sri Lanka 2011. Free Paper

58.L.I.K Silva  and S.S.S.B.D.P. Soysa,  "Antiproliferative activity and induction of apoptosis by a decoction prepared from Adenanthera pavonina and Thespesia populnea"  "International Conference on Stem Cells and Cancer (ICSCC-2010): Proliferation, Differentiation and Apoptosis", 11-14 December,2010 Pune, India.

59.L.I.K Silva, S.S.S.B.D.P. Soysa. Antioxidant and cytotoxic activities of a decoction prepared from Adenanthera pavonina (madatiya) and Thespesia populnea (gansuriya).  Proceedings of the 66th Annual Sessions of Sri Lanka Association for Advancement of Science.2010, p76.

60.A.A.S.Adikaryand S.S.S.B.D.P. Soysa. Comparison of cell viability of black, green and white tea (Camellia sinensis) manufactured in Sri Lanka. Proceedings of the 66th Annual Sessions of Sri Lanka Association for Advancement of Science 2010, p99.

61.Adikary A.A.S and Soysa S.S.S.B.D.P. High grown Sri Lankan black tea extract without the polyphenolic components does not show cytotoxic and antioxidant activities. Fourth Global Summit on Medicinal Aromatic Plants; Sarawak. Kuching Malaysia.1st-5th December 2009

62.Kulathunga Nilukshi, Pathirana W and  Soysa S.S.S.B.D.P. (2009) Annual Academic Sessions of Open University Sri Lanka 118.

63.P.A.R Senali and  Soysa S.S.S.B.D.P (2009) Absorption and serum protein binding of tea polyphenols in rats, after administration of caffeine with tea extract. Proceedings of the Annual Sessions of Sri Lanka Association for Advancement of Science.

64.Rathnayaka R.M.B.I. and Soysa S.S.S.B.D.P. (2009) Absorption of polyphenols and the effect on serum antioxidant activity after consumption of coriander (Coriandrum sativum), seed extract Proceedings of the Annual Sessions of Sri Lanka Association for Advancement of Science

65.Adikary A.A.S and Soysa S.S.S.B.D.P (2009 ) Comparison of the antioxidant activity of Black, Green and White Tea Proceedings of the Annual Sessions of Sri Lanka Association for Advancement of Science

66.Samaranayake NR , Soysa SSSBDP (2008), Kariyawasam H,  Important issues in pregnant epileptics, Annual Session of Institiute of Biology

67.Ihalagamage, P.J and Soysa S.S.SB.D.P. Study on antiproliferative activity of a selected decoction used for cancer therapy in Sri Lanka 1st International Conference in Holistic Medicine-Kottayam, Kerala, India. August 21-23, 2008.

68.B.M.MJ.Mendis, M.D.J Wijebandara and S.S.S.B.D.P Soysa Characterization of Biological Activity of Fleuggea leucopyrus Wild (Katupila).Proceedings of the Annual Sessions of Sri Lanka Association for Advancement of Science.

69.Manikpurage, I.P, Abeythunga D.T.U and S.S.S.B.D.P Soysa Anti-oxidant activity of Pleurotus cystidiosus . Proceedings of the Annual Sessions of Sri Lanka Association for Advancement of Science.

70.De Silva Savan Kalna, Ariyadasa Hirantha and Soysa S.S.S B.D.P,Study on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity in relation to the phenolic and gallic acid content in four medicinal plants used for cancer therapy in Sri Lanka Proceedings of the Annual Sessions of Sri Lanka Association for Advancement of Science

71.M.G.A.N. Perera S,S.S.S.B.D P. Soysa, A.A.S. Adikary, D.T.U. Abeytunga  (2007) Society for integrative oncology, Fourth International Conference Expanding Horizons in Collaborative Cancer Care, San Francisco, California, November 15-17, 2007. Total phenolic and gallic acid content strongly associate with antioxidant and cytotoxic properties of three traditional decoctions used for treatment of cancer in Sri Lanka

72.Widyalankara Anuradhi, Soysa SSSBDP (2007). Drug interactions, The effect of Corriander extract on paracetamol pharmacokinetics in rats. Proceedings of the Annual Sessions of Sri Lanka Association for Advancement of Science, 62

73.Senarathna SMDKG, S Sri Ranganathan, P Soysa,BMR Fernandopulle (2007) Colorimetric Technique: a cheaper method to assess the risk of hepatotoxicity in patients with acute paracetamol poisoning 6th Asia Pacific Medical Copngress, Bangkok

74.SMDKG Senarathna, S Sriranganathan, P Soysa, , BMR Fernandopulle (2007). Cost current management of acute paracetamol poisioning. Annual Session of  Sri Lanka Medical Association

75.SMDKG Senarathna, S Sri Ranganathan, P Soysa, N Freemantle, BMR Fernandopulle (2007). History of  ingested dose and plasma paracetamol levels in for the risk assessment in a acute paracetamol poisioning in resourced limited setting. International conference in Toxicology -

76.Senarathna SMDKG, Sri Ranganathan S, Soysa P, Fernadopulle R. (2006). The economical burden of current management of patients with acute paracetamol poisioning in a tertiary care hospital of Sri Lanka. Presented in Annual Conference  for South Asian Clinical Toxicological Research Collaboration 

77.Wijayawardena MAA, Soysa SSSBDP (2005). Proceedings of the Annual Sessions of Sri Lanka Association for Advancement of Science, 60 ,74-75. The effect of cammellia sinensis  (tea ) on paracetamol pharmacokinetics in rats.

78.Abhayaruwan MMGNK, Soysa SSSBDP and Andrahennadi TP (2004) Proceedings of the Annual Sessions of Sri Lanka Association for Advancement of Science; 59,  227. Pharmacokintics of caffeine in rats following administration of caffeine, caffeine with tea infusion and caffeine with tea cream.

79.Soysa SSSBDP, Udugama MIK (2002). Proceedings of the Annual Sessions of Sri Lanka Association for Advancement of Science 58 265 A simple colorimetric method for estimation of polyphenols present in tea – Comparative study with vanillin reagent.

80.Soysa SSSBDP, Udugama MJK, Andrahennadi TP (2002). Proceedings of the Annual Sessions of Sri Lanka Association for Advancement of Science 58, 266. The effect of tea and polyphenol free tea extracts on protein binding of caffeine in rats.

81.Fernandopulle M, Fernandopulle BMR, SriRanganathan S, Sathiadas MG, Soysa SSSBDP, Thalwattegedara C Jamburuthugoda V, (2001). Annual Sessions of Sri Lanka Medical Association Abstracts p55, Paracetamol toxicity in children

82.Galahitiyawa MW, Jayawardena MIFP and and Soysa P (2001). Abstracts Annual Academic sessions, p 22. Faculty of Medicine, University of Sri Jayawardenapura. Estimation of Vitamin A content in pasteurized milk during storage.

83.Silva WAIC, Soysa SSSBDP, Karunanayake EH (2000).. Preliminary studies on absorption and elimination of (-) epigallocatechin gallate in rats. Proceeding of the Annual Sessions of Sri Lanka Association for Advancement of Science, 56, p 261

84.Silva WAIC, Soysa SSSBDP, Karunanayake EH (2000). Determination of (-)  - epigallocatechin -3-gallate in biological fluids. Proceeding of the Annual Sessions of Sri Lanka Association Advancement of Science, 56, p267,

85.Soysa SSSBDP, Karunanayake EH (1998). Absorption and demethylation of caffeine in rat following administration of caffeine, caffeine with tea and caffeine with polyphenol free tea infusions. Proceeding of the Annual Sessions of Sri Lanka Association for Advancement of Science, 54, p 36.

86.Soysa SSSBDP, Karunanayake EH (1992). Effect of tea on caffeine metabolism. Proceeding of the Annual Sessions of Sri Lanka Association for Advancement of Science, 48, p 07.

87.Soysa SSSBDP and Karunanayake EH (1991). Study of the distribution of caffeine and its metabolites in tissue sub-cellular fractions. Proceeding of the Annual Sessions of Sri Lanka Association for Advancement of Science, 47, p 05.

88.Soysa SSSBDP and Karunanayake EH (1984), Further studies on interactions of tea on caffeiene metabolism. Proceeding of the Annual Sessions of Sri Lanka Association for Advancement of Science, 40, p 01

89.Karunanayake EH, Jayawardena SSSBDP and Weerasena HR (1984). A reverse phase HPLC procedure for the measurement of theophylline and caffeine in biological fluids. Proceeding of the Annual Sessions of Institute of Chemistry, Sri Lanka, p 07-08.

90.Karunanayake EH, Jayawardena SSSBDP and Roberts G (1983), Effects of tea on tissue distribution of caffeine. Proceeding of the Annual Sessions of Sri Lanka Association for Advancement of Science, 39, p 03-04.

91.Karunanayake EH, Jayawardena SSSBDP and Roberts G (1983),  Effects of tea on absorption and excretion of caffeine. Proceeding of the Annual Sessions of Sri Lanka Association for Advancement of Science, 39, p 03.

92.Karunanayake EH, Jayawardena SSSBDP (1982). A study of the effect of tea on caffeine metabolism. Proceeding of the Annual Sessions of Institute of Chemistry, Sri Lanka.   p 7-8.

 Contact Information

email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Official Address: Department of Biochemistry and Molecular Biology, Faculty   of Medicine Colombo, Sri Lanka

T.P No: 2697947