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Personal Details

 

Dr. Kalum Wetthasinghe 
MD, MSc, PhD,
Senior Lecturer in Anatomy 
MD (Latvia), MSc (Latvia), PhD (Colombo)

Biography

  Dr Kalum Wetthasinghe is a Medical Geneticist. Her special interests are Genetics & Genomic Medicine; Research and Development. She is currently the Coordinator of the Masters of Science program in Molecular pathology; Coordinator of Technology Transfer Office (TTO) of the Research Promotion and Facilitation Centre (RPFC), Faculty of Medicine, Colombo, a Committee Member of the Research and Higher Degree’s Committee (RHDC); Member of the Extended Courses committee and the convenor of the Special Senses Module at the Faculty of Medicine, University of Colombo.

Positions 

 

 

Position

Address

From

To

 Senior Lecturer in Anatomy

 Department of Anatomy, Faculty of Medicine, University of Colombo

 October 2014

 To date

Education & Training

 

Degrees, Diplomas etc.

Date Conferred

Results(give Class or Grade)

MD

 July 2002

 

MSc

 July 2003

 

PhD 

 May 2013

 

Honors, Awards and Grants

 

 

Honors

 

Awards 

 

  • President’s Awards for Scientific Publication 2013. This award scheme is administered by the National Research Council, Sri Lanka.Conference
  • One of the outstanding poster presentation awards at the International conference on Frontiers in Molecular Life Sciences. September 16 -18, 2009. Colombo, Sri Lanka was awarded to: Wettasinghe TK, Jayasekara RW, Dissanayake VHW. Absence of Y chromosome microdeletions in a Cohort of Male Partners from Couples with Spontaneous Recurrent Pregnancy loss. International conference on Frontiers in Molecular Life Sciences. September 16 -18, 2009. Colombo, Sri Lanka. (Abstracted in the Proceedings of the Conference:35).

Grants

 

  • 2016] National Science Foundation. Grant No: RPHS/2016/C03 – Rs. 5,000,000/- As inititial funding for the project titled “The Sri Lankan Inherited Cancer Biobank (ICBB) & The Sri Lankan Inherited Cancer Genetic Variation Database (ICGVDb).Role: Co- investigator Investgator.
  • [2015] University of Colombo – Collaborative Grant – Rs. 3,000,000/- As funding for the research project “Clinical and Molecular Genetic Studies in a Cohort of Sri Lankan Patients with Inherited Cancer Syndromes”.

Research with abstracts

 

Research Interests

 Dr Wetthasinghe’s research interests include Genetics & Genomic Medicine; Research and Development.

Appointments

 

 

 

Appointments

 2017 – Present - Coordinator, Technology Transfer Office (TTO) of the Research Promotion and Facilitation Centre (RPFC), Faculty of Medicine, Colombo

Memberships

 

  • 2005 – Present Life member, Sri Lanka Medical Association 
  • 2013 – 1014 Research supervisor Master of Science degree Program, Faculty of Medicine, University of Colombo
  • 2014 – Present Member of the Research and Higher Degrees Committee, Faculty of Medicine, University of Colombo
  • 2024 – Present Member of the Strategic and Planning Committee, Faculty of Medicine, University of Colombo
  • 2014 – Present Member of the IT Committee, Faculty of Medicine, University of Colombo
  • 2024 – Present Member of the Extended Courses Committee, Faculty of Medicine, University of Colombo

Undergraduate

 2014 – Present Convener, Special Senses Module, Faculty of Medicine, University of Colombo. 

Postgraduate

 2014 – Present Course coordinator, Master of Science degree Program, Faculty of Medicine, University of Colombo

Projects

  

Publications

 

 

 

 

 

Books/Book Chapter 

 

  • Sirisena N, Sumathipala D, Wettasinghe K, Dissanayake VHW. The provision of medical and health genetics and genomics in the developing world. In Dhavendra Kumar and Stylianos Antonarakis Ed. Medical and Health Genomics. Elsivier, 2016, 285-294. [ISBN: 9780124201965]

Conference Paper 

 

Internetional

  • Dissanayake VHW, Sirisena N, Sumathipala D, Wetthasinghe K, Jayasekara RW. Implementation of Genomic Medicine in Sri Lanka. 13th International Congress of Human Genetics. 2 to 8 April 2016. Kyoto, Japan. (Abstracted in the proceedings of the conference.)
  • Jayawardena SMA, Weththasinghe KT, Sumathipala D, Goonasekara HWW, Dissanayake VHW. Haematological Characteristics of a cohort of Sri Lankan patients with a-3.7 and a-4.2 deletions. 2nd PanAsian Conference on Haemoglobinopathies, 26-27 September 2015, Hanoi, Vietnam. (Abstracted in the Proceedings of the Conference, 68)
  • Wettasinghe TK, Jayasekara RW, Dissanayake VHW. Absence of Y chromosome microdeletions in a Cohort of Male Partners from Couples with Spontaneous Recurrent Pregnancy loss. International conference on Frontiers in Molecular Life Sciences. September 16 -18, 2009. Colombo, Sri Lanka. (Abstracted in the Proceedings of the Conference:35). This paper was judged as one of the “outstanding poster presentations” at the conference.
  • Gunathilake VW, Andraweera PH, Wetthasinghe TK, De Saram EMNR, Perera VS, Dissanayake VHW, Jayasekara RW. Chromosomal abnormalities in Sri Lankan women with Primary Amenorrhoea. International conference on Frontiers in Molecular Life Sciences. September 16 -18, 2009. Colombo, Sri Lanka. (Abstracted in the Proceedings of the Conference:35)
  • Wetthasinghe, TK, Mallawarachchi PHR, De Saram EMNR, Perera VS, Dissanayake VHW, Jayasekara RW. Chromosomal abnormalities in Sri Lankan women with primary amenorrhoea. ICOGEN ‘07, International Conference and Workshop on Genetics: The basis and diagnosis of genetic disorders. February 1-4, 2007. Chennai, India. (Abstracted in the proceedings of ICOGEN ‘07, 51) [This paper was awarded the prize for the best paper].
    • National
  • Kidnapillai S, Wettasinghe KT, Sirisena UND, Dissanayake VHW. Validation of a multiplex Tetra-primer amplification refractory mutation system (T-ARMS) PCR Assay to Genotype APOE Alleles. University of Colombo Annual Research Symposium 2014, November 20-21, 2014, Colombo. Sri Lanka. (Abstracted in the Proceedings of the Conference, p133)
  • Godapitiya IUH, Wettasinghe KT, Sirisena UND, Dissanayake VHW. Validation of a novel genotyping assay for CYP2C9, CYP4F2 and GGCX polymorphisms to predict warfarin maintenance dose. University of Colombo Annual Research Symposium 2014, November 20-21, 2014, Colombo. Sri Lanka. (Abstracted in the Proceedings of the Conference, p135)
  • Jayawardana SMA, Wetthasinghe TK, Sumathipala D, Goonasekera HWW, Dissanayake VHW. Phenotypic characteristics of a cohort of patients with –α3.7 and –α4.2 deletions. University of Colombo Annual Research Symposium 2014, November 20-21, 2014, Colombo. Sri Lanka. (Abstracted in the Proceedings of the Conference, p137)
  • Gunathilake KMD, Wettasinghe KT, Sirisena UND, Dissanayake VHW. Determination of frequency of HLA-B*1502 allele carriers in a cohort of Sri Lankans by HLA-B*1502 sequence specific polymerase chain reaction. University of Colombo Annual Research Symposium 2014, November 20-21, 2014, Colombo. Sri Lanka. (Abstracted in the Proceedings of the Conference, p138-9)
  • Kulathunga LAN, Wettasinghe KT, Sirisena UND, Dissanayake VHW. Implementation of an Allele Specific Amplification Refractory Mutation System Polymerase Chain Reaction (AS-ARMS-PCR). University of Colombo Annual Research Symposium 2014, November 20-21, 2014, Colombo. Sri Lanka. (Abstracted in the Proceedings of the Conference, p144-5)
  • Godapitiya IUH, Wettasinghe KT, Sirisena UND, Dissanayake VHW. Validation of a tetra primer amplification refractory mutation system polymerase chain reaction genotyping assay for cyp2c19*2 and cyp2c19*17 polymorphisms. University of Colombo Annual Research Symposium 2014, November 20-21, 2014, Colombo. Sri Lanka. (Abstracted in the Proceedings of the Conference, p174)
  • Somadasa PKDCT, Wettasinghe KT, Sirisena UND, Dissanayake VHW. Design and implementation of a new assay for genotyping pharmocogenomicaly important Cytochrome P450 2D6 (CYP 2D6) gene variants. University of Colombo Annual Research Symposium 2014, November 20-21, 2014, Colombo. Sri Lanka. (Abstracted in the Proceedings of the Conference, p176)
  • Banstola SR, Wettasinghe TK, Sirisena UND, Dissanayake VHW. Design and implementation of allele specific polymerase chain reaction (AS-PCR) assay to Genotype the V600E mutation in the BRAF gene. University of Colombo Annual Research Symposium 2014, November 20-21, 2014, Colombo. Sri Lanka. (Abstracted in the Proceedings of the Conference, p189)
  • Gautam B, Wetthasinghe TK, Sirisena UND, Dissanayake VHW. Design and implementation of novel allele specific multiplex polymerase chain reaction assay to genotype the exon 19 deletion and L858R mutation in the EGFR gene in patients with non-small cell lung carcinoma. University of Colombo Annual Research Symposium 2014, November 20-21, 2014, Colombo. Sri Lanka. (Abstracted in the Proceedings of the Conference, p190)
  • Wetthasinghe TK, Banstola SR, Sirisena UND, Dissanayake VHW. Design and implementation of a polymerase chain reaction (PCR) test to genotype the CCR5 delta 32 base pairs deletion. University of Colombo Annual Research Symposium 2014, November 20-21, 2014, Colombo. Sri Lanka. (Abstracted in the Proceedings of the Conference, p192)
  • Jeerasinghe PB, Wettasinghe KT, Sirisena ND, Dissanayake VHW. Design and implementation of a new assay to genotype 460G>A and 719A>G polymorphisms in the Thiopurine S-methyltransferase (TPMT) gene. University of Colombo Annual Research Symposium 2014, November 20-21, 2014, Colombo. Sri Lanka. (Abstracted in the Proceedings of the Conference, p194)
  • Wettasinghe TK, Dissanayake VHW, Jayasekara RW. AZFc partial deletions in male partners of women with spontaneous recurrent pregnancy loss in Sri Lanka. 42nd Annual Scientific Sessions of the Sri Lanka College of Obstetricians and Gynaecologists. November 13-15, 2009. Colombo, Sri Lanka. (Abstracted in the Sri Lanka Journal of Obstetrics and Gynaecology 2009,31(1): 71).
  • Wetthasinghe TK, Andraweera PH, Dissanayake VHW, Jayasekara RW. Genetic Abnormalities in Women With Primary amenorrhoea and Masculine Features. 41st Annual Academic Sessions of the Ceylon College of Physicians, October 2-4, 2008. (Abstracted in the Proceedings of the Annual Academic Sessions of the CCP, 46)
  • Wetthasinghe TK, Dissanayake VHW, Jayasekara RW. A descriptive study on the role of Y chromosome microdeletions in spontaneous recurrent pregnancy loss. 41st Annual Scientific Sessions of the Sri Lanka College of Obstetricians and Gynaecologists, June 27-29, 2008. Colombo, Sri Lanka. (Abstracted in the Sri Lanka Journal of Obstetrics and Gynaecology 2008,30 (suppl 1),98)
  • Dissanayake VHW, Andraweera PH, Wetthasinghe TK, Perera VS, De Seram EMNR, Athapaththu AMMH, Opanayaka DJS, Hidellage NT, Pedurupillay CRJ, Jayasekara RW. The cytogenetic profile of children with Down Syndrome. 121st Annual Scientific Sessions of the Sri Lanka Medical Association. March 19-22, 2008. Colombo, Sri Lanka. (Abstracted in the Ceylon Medical Journal 2008, 53 (Suppl 1): 17)
  • Andraweera PH, Wetthasinghe TK, Dissanayake VHW, Jayasekara RW. A case series of true hermaphrodites. 121st Annual Scientific Sessions of the Sri Lanka Medical Association. March 19-22, 2008. Colombo, Sri Lanka. (Abstracted in the Ceylon Medical Journal 2007, 53 (Suppl 1): 17)
  • Dissanayake VHW, Weerasekera LY, Gammulla CG, Andraweera PH, Wetthasinghe TK, Goonasekera HWW, Jayasekara RW. Genetic thrombophilic polymorphisms and pregnancy complications. 121st Annual Scientific Sessions of the Sri Lanka Medical Association. March 19-22, 2008. Colombo, Sri Lanka. (Abstracted in the Ceylon Medical Journal 2008, 53 (Suppl 1): 30)
  • Dissanayake VHW, Andraweera PH, Wetthasinghe TK, Perera VS, De Seram EMNR, Athapaththu AMMH, Opanayaka DJS, Hidellage NT, Pedurupillay CRJ, Jayasekara RW. Cytogenetic diagnostic services in Sri Lanka 2006-2007. 121st Annual Scientific Sessions of the Sri Lanka Medical Association. March 19-22, 2008. Colombo, Sri Lanka. (Abstracted in the Ceylon Medical Journal 2008, 53 (Suppl 1):57)
  • Wetthasinghe TK, Mallawarachchi PHR, De Saram EMNR, Perera VS, Dissanayake VHW, Jayasekara RW. Chromosomal abnormalities in Sri Lankan women with primary amenorrhoea. 39th Annual Scientific Sessions of the Sri Lanka College of Obstetricians and Gynaecologists. October 20-22, 2006. Colombo, Sri Lanka. (Abstracted in Sri Lanka Journal of Obstetrics and Gynaecology 2006;28(Suppl1): 36-37)

Journal Paper 

 

  1. Sirisena ND, Neththikumara N, Wetthasinghe K, Dissanayake VHW. Implementation of genomic medicine in Sri Lanka: Initial experience and challenges. Applied and Translational Genomics. 9 (2016) 33–36. doi: 10.1016/j.atg.2016.05.003
  2. [IF 2.138] Gunathilake KDM, Wettasinghe KT, Dissanayake VHW. A study of HLA-B1502 in a Sri Lankan Population: Implications for pharmacogenomic testing. Human Immunology. 2016 Apr 6. pii: S0198-8859(16)30041-6. doi: 10.1016/j.humimm.2016.04.001.
  3. Wettasinghe TK, Jayasekara RW, Dissanayake VHW. The low frequency of Y chromosome microdeletions in subfertile males in the Sinhalese population of Sri Lanka. Indian Journal of Human Genetics 2012;18(3):320-325. doi:10.4103/0971-6866.107985
  4. [IF 0.931] Samarakoon L, Sirisena ND, Wettasinghe KT, Kariyawasam KWJC, Jayasekara RW, Dissanayake VHW. Prevalence of chromosomal abnormalities in Sri Lankan women with primary amenorrhea. Journal of Obstetrics and Gynaecology Research 2013;39(5): 991–997. doi:10.1111/j.1447-0756.2012.02063.x. Epub 2012 Dec.
  5. IF 4.585] Wettasinghe TK, Jayasekara RW, Dissanayake VHW. Y chromosome microdeletions are not associated with spontaneous recurrent pregnancy loss in a Sinhalese population in Sri Lanka. Human Reproduction 2010;25(12):3152-6. doi:10.1093/humrep/deq271. Epub 2010 Oct 13
  6. Wetthasinghe TK, Sirisena ND, Andraweera PH, Jayasekara RW, Dissanayake VHW. A Case Series of Five Sri Lankan Patients with Ovotesticular Disorder of Sex Development. Clinical Pediatric Endocrinology, 2012;21(4):69-73. doi:10.1297/cpe.21.69. Epub 2012 Oct 30.

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 Department of Anatomy, Faculty of Medicine, University of Colombo, Kynsey Road, Colombo 08, Sri Lanka  

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 Phone

 +942695300 

 Ext

 234/119

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