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Details

Personal Details

 

DR. (MISS) ULLUSIHEWAGE NIRMALA DUSHYANTHI SIRISENA, MBBS, MSc in Clinical Genetics, CTHE SEDA (UK).
Senior Lecturer and Clinical Geneticist
Department of Anatomy
Faculty of Medicine
University of Colombo, Sri Lanka

 

Biography

  Dr. Sirisena is a Clinical Geneticist. Her special interests are Clinical Genetics, Cancer Genomics & Genomic Medicine. She is currently a Senior Lecturer and Clinical Geneticist in the Department of Anatomy/Human Genetics Unit, Faculty of Medicine from September 2014 to date.

Positions 

 

 

Position

Address

From

To

 Senior Lecturer in Anatomy

 

Faculty of Medicine,

University of Colombo

 September 2014

 Date

 Lecturer in Anatomy

 

Faculty of Medicine,

University of Colombo

 April 2013

 September 2014

Education & Training

 

Degrees, Diplomas etc.

Date Conferred

Results(give Class or Grade)

 MBBS  August 1991  
MSc in Clinical Genetics August 2012  

Honors, Awards and Grants

 

 

Honors

 

Honours

Selective participant at the International Summit in Human Genetics and Genomics, hosted by the National Human Genome Research Institute (NHGRI), at the National Institutes of Health (NIH), Bethesda, USA from Sept.1-30th, 2016.

 

Awards 

 

International Conference Awards

Korean Breast Cancer Foundation Scholarship award for outstanding oral presentation at the Global Breast Cancer Conference 2017 at Jeju Island, South Korea from 20th – 22nd April 2017 for the paper: Genetic determinants of sporadic breast cancer in a cohort of Sri Lankan postmenopausal women: Nirmala D. Sirisena, Anchala Kuruppu, Adebowale Adeyemo, Nilaksha Neththikumara, Nilakshi Samaranayake, Vajira H. W. Dissanayake. This paper was based on my ongoing PhD research study (Abstracted in the proceedings of the conference, p.112).

Daphne Attygalle Award for the best paper in Cancer at the Sri Lanka Medical Association 130th Anniversary International Medical Congress 2017 for the poster presentation titled “Implementation of Multi-Gene Panel Testing for Hereditary Cancer Predisposition in Sri Lanka: Initial Experiences” (Sirisena UND, Neththikumara N, Wetthasinghe K, Herath L, Dissanayake VHW).

The certificate for the best poster presentation of a case report. Awarded by the Assembly of Asia Pacific International Academy of Pathology and The College of Pathologists of Sri Lanka at the Diagnostic Pathology Update and Junior Academy International Conference 2014 held in Colombo, Sri Lanka from 27 to 29 August 2014 was awarded to: Gautam B, Sirisena UND, Dissanayake NDW, Dissanayake VHW. BRCA1 mutation is three Sri Lanka families with hereditary breast and ovarian cancer syndrome (Abstracted in the proceedings of the conference 2014, p.58).

National Awards

International Travel Grant Award by the University of Colombo to participate at the Global Breast Cancer Conference 2017 in Jeju Island, South Korea from 20th – 22nd April 2017 for oral presentation of a paper titled – “Genetic determinants of sporadic breast cancer in a cohort of Sri Lankan postmenopausal women”.

Merit award for Scientific Publications in 2016. This award scheme is administered by the National Research Council, Sri Lanka.

International Travel Grant Award by the National Science Foundation, Sri Lanka to deliver an oral presentation of a paper titled – “Initial Experience in Implementation of a Cancer Gene Panel Test to Determine the Aetiology of Breast Cancer in a Developing Country” at the Human Genome Meeting 2015 Conference held at the Kuala Lumpur Convention Centre, Malaysia from 14 – 17 March 2015.

 

Grants

 

  1. [2015] Grant Ref No: AP/3/2/2015/PG/07 - University of Colombo PhD Research Scholarship – Rs. 1,500,000Role: Principle Investigator - 01/02/15 – 01/05/18Research Title: Molecular genetic determinants of sporadic breast cancer in a cohort of Sri Lankan postmenopausal women.
  2. [2015] Grant Ref No: UGC/DRIC/PG/2015(i)/CMB/01 - University GrantsCommission PhD Research Grant – Rs. 3,300,000Role: Principle Investigator - 01/05/15 – 01/05/18Research Title: Molecular genetic determinants of sporadic breast cancer in a cohort of Sri Lankan postmenopausal women.
  3. [2016] National Science Foundation. Grant No: RPHS/2016/C03 – Rs. 5,000,000/-Role: Co-Investigator - As initial funding for the project titled “The Sri Lankan Inherited Cancer Biobank (ICBB) & The Sri Lankan Inherited Cancer Genetic Variation Database (ICGVDb).
  4. [2015] University of Colombo – Collaborative Grant – Rs. 3,000,000/-Role: Co-investigator - As funding for the research project Clinical and Molecular Genetic Studies in a Cohort of Sri Lankan Patients with Inherited Cancer Syndromes.
  5. [2016] University of Alabama, Birmingham – Comprehensive Cancer Centre Research Grant Role: Co-Investigator - 01/12/16 – 01/11/17Research Title: HPV Transmission Probabilities in Heterosexual Couples in Sri Lanka.

 

Research with abstracts

 Refer to section on conference papers.

Research Interests

 

Dr. Sirisena’s research interests include Cancer Genetics and Genomic Medicine.

Appointments

 

 

 

Appointments

 

Memberships

 

Editorial Board MemberSri Lanka Journal of Anatomy – From Dec 2016.

 

Membership in Professional Associations

Life Member, Sri Lanka Medical Association From 2012.

Undergraduate

 
  1. Convenor, Blood & Lymphoreticular System Module – March 2015 to date.
  2. Member, Electives Committee – Oct 2013 to date.

Postgraduate

 
  1. Course Co-ordinator, MSc in Genetic Diagnostics, Faculty of Medicine, University of Colombo – August 2013 – May 2015.
  2. Course Co-ordinator, MSc in Clinical Genetics, Faculty of Medicine, University of Colombo – June 2015 to date.

Projects

  

  1. Molecular genetic determinants of sporadic breast cancer in a cohort of Sri Lankan postmenopausal women.
  2. Clinical and Molecular Genetic Studies in a Cohort of Sri Lankan Patients with Inherited Cancer Syndromes.
  3. The Sri Lankan Inherited Cancer Biobank (ICBB) & The Sri Lankan Inherited Cancer Genetic Variation Database (ICGVDb).

Publications

 

 

Books/Book Chapter 

 
  1. Nirmala Sirisena, Niluka Dissanayake, Vajira H.W. Dissanayake. Annex 1 -  Hereditary Breast Cancer in Early Detection and Management of Breast Symptoms - National Guideline for Primary Care Doctors and Family Physicians published by the National Cancer Control Programme, Ministry of Health, Sri Lanka, Second Edition January 2014.
  2. Sirisena, N.D., Sumathipala, D., Wetthasinghe, K., Dissanayake, V.H.W. (2016). The Provision of Medical and Health Genetics and Genomics in the Developing World. In: Kumar, D. and Antonarakis, S. (ed.) Medical and Health Genomics. Elsevier – Academic Press, Cambridge.
  3. Rohan W. Jayasekara Felicitation volume. First published September 2015. Edited by Dr. Nirmala D. Sirisena, Department of Anatomy, Faculty of Medicine, University of Colombo, Sri Lanka, 2015 - National Library of Sri Lanka – Cataloguing in Publication Data [ISBN 978-955-0460-70-0].

Conference Paper 

 INTERNATIONAL

  1. Sirisena UND, Adeyemo A, Kuruppu AI, Neththikumara N, Samaranayake N, Dissanayake VHW. Genetic determinants of sporadic breast cancer in Sri Lankan women. Paper selected for oral presentation at the 130th Anniversary International Medical Congress of the Sri Lanka Medical Association. Ceylon Medical Journal, Vol 62 Supplement 1, July 2017; p. 77.
  2. Sirisena UND, Neththikumara N, Wetthasinghe K, Dissanayake VHW. The results of the first 25 clinical exomes tested in the Sri Lankan population. Paper selected for oral presentation at the 130th Anniversary International Medical Congress of the Sri Lanka Medical Association. Ceylon Medical Journal, Vol 62 Supplement 1, July 2017; p. 83.
  3. Sirisena UND, Neththikumara N, Wetthasinghe K, Herath L, Dissanayake VHW. Implementation of multi-gene panel testing for hereditary cancer predisposition in Sri Lanka: initial experiences. Paper selected for poster presentation at the 130th Anniversary International Medical Congress of the Sri Lanka Medical Association. Ceylon Medical Journal, Vol 62 Supplement 1, July 2017; p. 183.
  4. Paththinige CS, Sirisena UND, Kariyawasam UGIU, Dissanayake VHW. The spectrum and frequency of chromosomal translocations in a cohort of Sri Lankan patients. Paper selected for poster presentation at the 130th Anniversary International Medical Congress of the Sri Lanka Medical Association. Ceylon Medical Journal, Vol 62 Supplement 1, July 2017; p. 265.
  5. Nirmala Sirisena, Anchala Kuruppu, Adebowale Adeyemo, Nilaksha Neththikumara, Nilakshi Samaranayake, Vajira H. W. Dissanayake. Genetic Determinants of Sporadic Breast Cancer in a Cohort of Sri Lankan Postmenopausal Women. This paper won the Korean Breast Cancer Foundation Scholarship award for outstanding oral presentation at the Global Breast Cancer Conference 2017 held at Jeju Island, South Korea, 20th – 22nd April 2017. (Abstracted in the proceedings of the conference, p. 112).
  6. N. Sirisena, N. Neththikumara, K. Wetthasinghe, V.H.W. Dissanayake. Pattern of germline variants detected in Sri Lankan patients referred for genetic evaluation of hereditary breast cancer using a multi-gene cancer panel test. Paper selected for oral presentation at the International Conference on Diagnostic Pathology of Breast and Female Genital Tract at the Annual Academic Sessions of the College of Pathologists of Sri Lanka 2016, 8th – 10th September 2016, Colombo, Sri Lanka. (Abstracted in the proceedings of the conference, p.24).
  7. UND Sirisena, Kemal Deen, Dayupathi EN Mandawala, MP Herath, VHW Dissanayake. The pattern of KRAS mutations in metastatic colorectal cancer: A retrospective study from Sri Lanka. Paper selected for oral presentation at the 45th Annual Academic Sessions of the College of Surgeons of Sri Lanka & Joint Meeting with the Royal College of Surgeons of Edinburgh held from 17th – 20th August 2016, Colombo, Sri Lanka. (Abstracted in the proceedings of the conference, p.32-33).
  8. Sirisena UND, Neththikumara N, Wetthasinghe TK, Dissanayake VHW. Implementation of a multi-gene cancer panel test for the detection of inherited breast cancer syndromes. Paper selected for poster presentation at the 129th Anniversary International Medical Congress of the Sri Lanka Medical Association held from 25th to 27th July 2016, Colombo, Sri Lanka. (Abstracted in the proceedings of the conference, p.170).
  9. Gunawardena BM, Gurusinghe SR, Halidha MSF, Hansika UHD, Sirisena UND. Knowledge, attitudes and practices related to hereditary cancer among medical officers in the surgical and gynaecological wards at three tertiary care hospitals in Colombo. Paper selected for oral presentation at the 129th Anniversary International Medical Congress of the Sri Lanka Medical Association held from 25th to 27th July 2016, Colombo, Sri Lanka. (Abstracted in the proceedings of the conference, p.145).
  10. Sirisena ND, Deen k, Mandawala DEN, Herath HMP, Dissanayake VHW. The pattern of KRAS mutations in Sri Lankan patients with colorectal cancer. Paper selected for oral presentation at the Second International Conference on Natural Products Genomics and Drug Discovery “Basic and Translational Research on Cancer and Inflammation” held from 23rd – 24th June 2016, Colombo, Sri Lanka. (Abstracted in the proceedings of the conference, p.19-20).
  11. Vajira H.W. Dissanayake, Nirmala Sirisena, Dulika Sumathipala, Kalum Wetthasinghe, Nilaksha Neththikumara, Rohan W. Jayasekara. Implementation of Genomic Medicine in Sri Lanka. Paper selected for poster presentation at the 13th International Congress of Human Genetics at the Kyoto International Conference Centre, Japan from 3-7 April 2016. (Abstracted in the proceedings of the conference, id:3420).
  12. L.A.N. Kulathunga, K.T. Wettasinghe, UND Sirisena, VHW Dissanayake. Implementation of an Allele Specific PCR for the analysis of VKORC1 1173C>T polymorphism (a pharmacogenomics biomarker) in a Sri Lankan cohort. Paper selected for oral presentation at the International Conference of Pharmaceutical Sciences and Medicines, Burapha University, Chonburi, Thailand, January 2015. (Abstracted in the proceedings of the conference, p.22).
  13. Sirisena UND, Abeysekara AAGS, Dissanayake VHW. Initial experience in implementation of a cancer gene panel test to determine the aetiology of breast cancer in a developing country – Paper selected for oral presentation at the Human Genome Meeting 2015 held in Kuala Lumpur, Malaysia from 14 - 17 March 2015. (Abstracted in the proceedings of the conference, p.57).
  14. Sirisena UND, Mandawala DEN, Herath HMP, Dissanayake VHW. The pattern of KRAS mutations in Sri Lankan patients with colorectal cancer. Paper selected for oral presentation at the 128th Anniversary International Medical Congress of Sri Lanka Medical Association, 6th-8th July 2015, Colombo. (Abstracted in the proceedings of the conference, p.146).
  15. Sirisena UND, Abeysekara AAGS, Dissanayake VHW. Initial experience in implementation of a cancer gene panel test to determine the aetiology of breast cancer in Sri Lanka. Abstract selected for poster presentation at the 128th Anniversary International Medical Congress of Sri Lanka Medical Association, 6th-8th July 2015, Colombo. (Abstracted in the proceedings of the conference, p.167).
  16. Wijerathne HGPK, Malalasekera AP, Sirisena UND, Kumaraguru K, Jayasekara RW, Dissanayake VHW. Chromosomal abnormalities in a cohort of infertile men in Colombo. Abstract selected for poster presentation at the 128th Anniversary International Medical Congress of Sri Lanka Medical Association, 6th-8th July 2015, Colombo. (Abstracted in the proceedings of the conference, p.213-4).
  17. De Silva KSH, Sirisena ND, Wijenayaka WAHK, Cooray MJG, Dissanayake VHW, Jayasekara RW. Androgen Insenstitivy Syndrome in a Cohort of Sri Lankan Children with 46,XY Disorders of Sex Development. 2nd South Asia Paediatric Association Conference and 18th Annual Congress of the Sri Lanka College of Paediatricians, 30 July – 2 August 2015, Colombo, Sri Lanka. (Abstracted in the Proceedings of the Conference, 35).
  18. Gautam B, Sirisena UND, Dissanayake NDW, Dissanayake VHW. BRCA1 mutation in three Sri Lankan families with hereditary breast and ovarian cancer syndrome. Diagnostic Pathology Update and Junior Academy International Conference 2014. Organised by the Assembly of Asia Pacific International Academy of Pathology and The College of Pathologists of Sri Lanka, Colombo, Sri Lanka. 27 to 29 August 2014. (Abstracted in the proceedings of the conference 2014, p.58). This communication won the certificate for the best poster presentation of a case report.
  19. Nirmala D. Sirisena, Kenneth McElreavey, Anu Bashamboo, K.S.H. de Silva, Rohan W. Jayasekara, Vajira H.W. Dissanayake. Child with a Homozygous Mutation in the Treacher Collins-Franceschetti Syndrome 1 gene (TCOF1) Presenting with Ambiguous Genitalia, Cranio-facial Dysmorphism and Multiple Congenital Malformations. Selected for poster presentation at the European School of Genetic Medicine, 27th Course in Medical Genetics held at Bertinoro, Italy, May 11-15, 2014. (Abstracted in the Programme & Abstract Book, p. 42-43).
  20. Sirisena ND, Abeysekara AAGS, de Silva KSH, Jayasekara RW, Dissanayake VHW. Clinical and genetic characterization of Androgen Receptor (AR) gene mutations in a cohort of Sri Lankan patients with 46,XY Disorders of Sex Development. International Conference on Birth Defects 2014, Colombo, Sri Lanka. 9 to 11 February 2014. (Abstracted in the Proceedings of the International Conference on Birth Defects 2014; p.33).
  21. Sirisena ND, McElreavey K, Bashamboo A, de Silva KSH, Jayasekara RW, Dissanayake VHW. A Child with a novel de novo mutation in the Aristaless Domain of the Aristaless-Related Homeobox (ARX) gene presenting with ambiguous genitalia. International Conference on Birth Defects 2014, Colombo, Sri Lanka. 9 to 11 February 2014. (Abstracted in the Proceedings of the International Conference on Birth Defects 2014; p.34).
  22. Kariyawasam UGIU, Sirisena ND, Udalamaththa AVLK, Hidellage NT, Sumanasena S, Jayasekara RW, Dissanayake VHW. Two siblings presenting with dysmorphism, developmental delay and intellectual disability due to partial trisomy 8p and partial monosomy 18p resulting from a maternal balanced translocation t(8;18)(p21.3;p11.23). International Conference on Birth Defects 2014, Colombo, Sri Lanka. 9 to 11 February 2014. (Abstracted in the Proceedings of the International Conference on Birth Defects 2014; p.31).
  23. Senaratne LDS, Gautham B, Sumathipala DS, Sirisena ND, Jayasekera RW, Dissanayake VHW. A case series of four Sri Lankan patients with 5p deletion. International Conference on Birth Defects 2014, Colombo, Sri Lanka. 9 to 11 February 2014. (Abstracted in the Proceedings of the International Conference on Birth Defects 2014; p.36).
  24. PB Jeerasinghe, UND Sirisena, RW Jayasekara, VHW Dissanayake. Prevalence of haemoglobin beta gene mutations in a cohort of Sri Lankan patients referred for β Thalassaemia Screening. Selected for oral presentation and abstracted in the proceedings of the 127th Anniversary International Medical Congress of the Sri Lanka Medical Association held on 17 July 2014 at the Bandaranaike Memorial International Conference Hall, Colombo, p.105.
  25. IUH Godapitiya, UND Sirisena, HWW Goonasekera, PKD Nisansala, RW Jayasekara, VHW Dissanayake. Prevalence of Factor V Leiden polymorphism in Sri Lankan patients referred for Thrombophilia screening. Selected for oral presentation and abstracted in the proceedings of the 127th Anniversary International Medical Congress of the Sri Lanka Medical Association held on 17 July 2014 at the Bandaranaike Memorial International Conference Hall, Colombo, p.105.
  26. LAN Kulathunga, UND Sirisena, HWW Goonasekera, PKD Nisansala, RW Jayasekara, VHW Dissanayake. Prevalence of MTHFR 677C>T (rs1801133) gene polymorphism in patients referred for thrombophilia screening in Sri Lanka. Selected for oral presentation and abstracted in the proceedings of the 127th Anniversary International Medical Congress of the Sri Lanka Medical Association held on 17 July 2014 at the Bandaranaike Memorial International Conference Hall, Colombo, p.106.
  27. S Kidnapillai, UND Sirisena, VHW Dissanayake. Prevalence of HLA-B27 allele in a cohort of Sri Lankan patients referred for suspected spondyloarthritides. Selected for poster presentation and abstracted in the proceedings of the 127th Anniversary International Medical Congress of the Sri Lanka Medical Association held on 17 July 2014 at the Bandaranaike Memorial International Conference Hall, Colombo, p.141.
  28. B Gautam, ND Sirisena, NDW Dissanayake, RW Jayasekara, VHW Dissanayake. Novel breast cancer susceptibility gene (BRCA1) mutations in Sri Lankan families with hereditary breast and ovarian cancer syndrome. Selected for poster presentation and abstracted in the proceedings of the 127th Anniversary International Medical Congress of the Sri Lanka Medical Association held on 17 July 2014 at the Bandaranaike Memorial International Conference Hall, Colombo, p.144.
  29. SR Banstola, ND Sirisena, DS Sumathipala, VHW Dissanayake, RW Jayasekara. Clinical and genetic features of Spinal Muscular Atrophy in Sri Lanka. Selected for poster presentation and abstracted in the proceedings of the 127th Anniversary International Medical Congress of the Sri Lanka Medical Association held on 17 July 2014 at the Bandaranaike Memorial International Conference Hall, Colombo, p.144.
  30. Sirisena ND, McElreavey KM, Bashamboo A, Jayasekara RW, Dissanayake VHW. A novel de novomutation in the aristaless domain of the ARX gene in a Sri Lankan male child with acquired microcephaly, psychomotor delay and ambiguous genitalia. Joint Conference of the Human Genome Meeting 2013 and 21st International Congress of Genetics, April 12-18, 2013. Singapore. (Abstracted in the proceedings of the conference, p.159).
  31. Sirisena UND, De Silva S, Jayasekara RW, Dissanayake VHW. Phenotypic features in a cohort of patients with 46, XY disorder of sex development (46,XY DSD) in Sri Lanka. 125th Anniversary International Medical Congress, Sri Lanka Medical Association. July 2 to 6, 2012. Colombo, Sri Lanka. (Abstracted in the Ceylon Medical Journal 2012, 57 (supple 1):92).
  32. Sirisena UND, De Silva S, Abeysekara AAGS, Jayasekara RW, Dissanayake VHW. Clinical and molecular genetic studies in a cohort of Sri Lankan patients with 46,XY disorder of sex development (46,XY DSD). 125th Anniversary International Medical Congress, Sri Lanka Medical Association. July 2 to 6, 2012. Colombo, Sri Lanka. (Abstracted in the Ceylon Medical Journal 2012, 57 (supple 1):94).
  33. Sirisena UND, Jayasekera RW, Dissanayake VHW. A descriptive study of children with ambiguous genitalia in SriLanka. Workshop on Disorders of Sexual Development: New Directions and Persistent Doubts. 14 - 15 October 2011. Bologna, Italy. (Abstracted in the proceedings of the workshop, 59).
      • NATIONAL
  34. I.U.H. Godapitiya, I. Kariyawasam, V. Udalamaththa, U.N.D. Sirisena, V.H.W. Dissanayake. Molecular Cytogenetic Characterization of the First Reported Sri Lankan Child with a De Novel 9p Inverted Duplication (p13.3p23). Paper selected for oral presentation at the Young Scientists Forum Symposium organized by the National Science and Technology Commission, January 2015. (Abstracted in the proceedings of the conference, p.81-84).
  35. Sirisena ND, Abeysekara AAGS, Dissanayake VHW. TP53 germline mutation in a Sri Lankan family with Li-Fraumeni syndrome. Annual Research Symposium on Cancer Prevention & Control 2014. National Cancer Control Programme. November 27, 2014. Colombo, Sri Lanka.
  36. Dissanayake NDW, Sirisena ND, Sumathipala D, Dissanayake VHW. Clinical characterization of a cohort of Sri Lankan families with inherited cancer syndromes.University of Colombo Research Symposium 2014, November 20-21, 2014, Colombo. Sri Lanka. (Abstracted in the Proceedings of the Conference, p.172).
  37. Kidnapillai S, Wettasinghe KT, Sirisena UND, Dissanayake VHW. Validation of a Multiplex Tetra-primer Amplification Refractory Mutation System (T-ARMS) PCR Assay to Genotype APOE Alleles. University of Colombo Research Symposium 2014, November 20-21, 2014, Colombo. Sri Lanka. (Abstracted in the Proceedings of the Conference, p.133).
  38. Godapitiya IUH, Wettasinghe KT, Sirisena UND, Dissanayake VHW. Validation of a tetra primer amplification refractory mutation system polymerase chain reaction genotyping assay for CYP2C19*2 and CYP2C19*17 polymorphisms. University of Colombo Research Symposium 2014, November 20-21, 2014, Colombo. Sri Lanka. (Abstracted in the Proceedings of the Conference, p.135).
  39. Gunathilake KMD, Wettasinghe KT, Sirisena UND, Dissanayake VHW. Determination of frequency of HLA-B*1502 allele carriers in a cohort of Sri Lankans by HLA-B*1502 sequence specific polymerase chain reaction. University of Colombo Research Symposium 2014, November 20-21, 2014, Colombo. Sri Lanka. (Abstracted in the Proceedings of the Conference, p.138).
  40. Kulathunga LAN, Wettasinghe KT, Sirisena UND, Dissanayake VHW. Implementation of an allele specific amplification refractory mutation system polymerase chain reaction (AS-ARMS PCR) genotyping assay for the 1173C>T polymorphism in the VKORC1 gene. University of Colombo Research Symposium 2014, November 20-21, 2014, Colombo. Sri Lanka. (Abstracted in the Proceedings of the Conference, p.144).
  41. Somadasa PKDCT, Wettasinghe KT, Sirisena UND, Dissanayake VHW. Design and implementation of a new assay for genotyping pharmocogenomicaly important Cytochrome P450 2D6 (CYP 2D6) gene variants. University of Colombo Research Symposium 2014, November 20-21, 2014, Colombo. Sri Lanka. (Abstracted in the Proceedings of the Conference, p.176).
  42. Banstola SR, Wettasinghe TK, Sirisena UND, Dissanayake VHW. Design and implementation of allele specific polymerase chain reaction (AS-PCR) assay to Genotype the V600E mutation in the BRAF gene. University of Colombo Research Symposium 2014, November 20-21, 2014, Colombo. Sri Lanka. (Abstracted in the Proceedings of the Conference, p.189).
  43. Gautam B, Wetthasinghe TK, Sirisena UND, Dissanayake VHW. Design and implementation of novel allele specific multiplex polymerase chain reaction assay to genotype exon 19 deletion and L858R mutation in the EGFR gene in patients with non-small cell lung carcinoma. University of Colombo Research Symposium 2014, November 20-21, 2014, Colombo. Sri Lanka. (Abstracted in the Proceedings of the Conference, p.190).
  44. Wetthasinghe TK, Banstola SR, Sirisena UND, Dissanayake VHW. Design and implementation of a polymerase chain reaction (PCR) test to genotype the CCR5 delta 32 base pairs deletion. University of Colombo Research Symposium 2014, November 20-21, 2014, Colombo. Sri Lanka. (Abstracted in the Proceedings of the Conference, p.192).
  45. Jeerasinghe PB, Wettasinghe KT, Sirisena ND, Dissanayake VHW. Design and implementation of a new assay to genotype 460G>A and 719A>G polymorphisms in the Thiopurine S-methyltransferase (TPMT) gene. University of Colombo Research Symposium 2014, November 20-21, 2014, Colombo. Sri Lanka. (Abstracted in the Proceedings of the Conference, p.194).
  46. Jeerasinghe PB, Sirisena ND, Kariyawasam I, Udalamaththa V, Dissanayake VHW. A maternally inherited partial trisomy 1q (q44qter) and partial trisomy 15 (pterq22) in a child with Silver Russell & Partial trisomy 15q Syndrome. University of Colombo Research Symposium 2014, November 20-21, 2014, Colombo. Sri Lanka. (Abstracted in the Proceedings of the Conference, p.196).
  47. Sirisena UND, McElreavey K, Bashamboo A, de Silva KSH, Jayasekara RW, Dissanayake VHW. Child with a novel homozygous mutation in the Treacher Collins-Franceschetti syndrome 1 (TCOF1) gene presenting with ambiguous genitalia, cranio-facial dysmorphism and multiple congenital malformations. University of Colombo Research Symposium 2014, November 20-21, 2014, Colombo. Sri Lanka. (Abstracted in the Proceedings of the Conference, p.197).
  48. Kulathunga LAN, Kariyawasam I, Udalamaththa V, Karunaratne HWSS, Senaratne LDS, Sirisena UND, Dissanayake VHW. Ring chromosome 21 in a child with dysmorphic features. University of Colombo Research Symposium 2014, November 20-21, 2014, Colombo. Sri Lanka. (Abstracted in the Proceedings of the Conference, p.199).
  49. Somadasa PKDCT, Udalamaththa AVLK, Kariyawasam UGIU, Jayawardana SMA, Sirisena UND, Dissanayake VHW. Molecular-cytogenetic analysis of a ring chromosome 18 in a Sri Lankan female child with congenital malformation, heart defects and global developmental delay. University of Colombo Research Symposium 2014, November 20-21, 2014, Colombo. Sri Lanka. (Abstracted in the Proceedings of the Conference, p.200).
  50. Gunathilake KMD, Kariyawasam UGIU, Udalamaththa AVLK, Sumathipala DS, Sirisena UND, Dissanayake VHW. A patient with Turner Syndrome with a karyotype of 45,X[38]/46,X,r(X)[16]. University of Colombo Research Symposium 2014, November 20-21, 2014, Colombo. Sri Lanka. (Abstracted in the Proceedings of the Conference, p.202).
  51. Gautam B, Udalamaththa AVLK, Kariyawasam UGIU, Sirisena UND, Dissanayake VHW. Paternally inherited chromosomal translocation (8;11) in a child with dysmorphic features and seizures. University of Colombo Research Symposium 2014, November 20-21, 2014, Colombo. Sri Lanka. (Abstracted in the Proceedings of the Conference, p.204).
  52. Banstola SR, Udalamaththa AVLK, Kariyawasam UGIU, Sirisena UND, Dissanayake VHW. A case report of a patient with mosaicism for ring chromosome 6 and monosomy 6 cell lines: FOXC1 gene deletion with no associated eye anomalies. University of Colombo Research Symposium 2014, November 20-21, 2014, Colombo. Sri Lanka. (Abstracted in the Proceedings of the Conference, p.205).
  53. Kidnapillai S, Kariyawasam UGIU, Sirisena UND, Dissanayake VHW. Partial monosomy of the long arm of chromosome 13 involving 13q32 band: a case report. University of Colombo Research Symposium 2014, November 20-21, 2014, Colombo. Sri Lanka. (Abstracted in the Proceedings of the Conference, p.207).
  54. Godapitiya IUH, Kariyawasam I, Udalamaththa V, Sirisena UND, Dissanayake VHW. Molecular cytogenetic characterization of the first reported Sri Lankan child with a de novo 9p inverted duplication (p13.3; p23). University of Colombo Research Symposium 2014, November 20-21, 2014, Colombo. Sri Lanka. (Abstracted in the Proceedings of the Conference, p.208). 

Journal Paper 

 

  1. Nirmala Dushyanthi Sirisena, Kemal Deen, Dayupathi Eranda Nipunika Mandawala, Pumindu Herath and Vajira Harshadeva Weerabaddana Dissanayake. The pattern of KRAS mutations in metastatic colorectal cancer: a retrospective audit from Sri Lanka. Sirisena et al. BMC Res Notes (2017) 10:392. DOI 10.1186/s13104-017-2731-5.
  2. Paul Kruszka, Antonio R. Porras, Yonit A. Addissie, Angélica Moresco, Sofia Medrano, Gary T. K. Mok, Gordon K. C. Leung, Cedrik Tekendo-Ngongang, Annette Uwineza, Meow-Keong Thong, Premala Muthukumarasamy, Engela Honey, Ekanem N. Ekure, Ogochukwu J. Sokunbi, Nnenna Kalu, Kelly L. Jones, Julie D. Kaplan, Omar A. Abdul-Rahman, Lisa M. Vincent, Amber Love, Khadija Belhassan. Karim Ouldim, Ihssane El Bouchikhi, Anju Shukla, Katta M. Girisha, Siddaramappa J. Patil, Nirmala D. Sirisena, Vajira H. W. Dissanayake, C. Sampath Paththinige, Rupesh Mishra, Eva Klein-Zighelboim, Bertha E. Gallardo Jugo, Miguel Chávez Pastor, Hugo H. Abarca-Barriga, Steven A. Skinner, Eloise J. Prijoles, Eben Badoe, Ashleigh D. Gill, Vorasuk Shotelersuk, Patroula Smpokou, Monisha S. Kisling, Carlos R. Ferreira, Leon Mutesa, Andre Megarbane, Antonie D. Kline, Amy Kimball, Emmy Okello, Peter Lwabi, Twalib Aliku, Emmanuel Tenywa, Nonglak Boonchooduang, Pranoot Tanpaiboon, Antonio Richieri-Costa, Ambroise Wonkam, Brian H. Y. Chung Roger E. Stevenson, Marshall Summar, Kausik Mandal, Shubha R. Phadke, María G. Obregon, Marius G. Linguraru and Maximilian Muenke. Noonan syndrome in diverse populations. Am J Med Genet Part A. 2017;1–12. https://doi.org/10.1002/ajmg.a.38362.
  3. Nirmala D. Sirisena and Vajira H. W. Dissanayake. Focusing attention on ancestral diversity within genomics research: a potential means for promoting equity in the provision of genomics based healthcare services in developing countries. J Community Genet. July 2017; DOI 10.1007/s12687-017-0311-y.
  4. CS Paththinige, ND Sirisena and VHW Dissanayake. Genetic determinants of inherited susceptibility to hypercholesterolemia – a comprehensive literature review. Lipids in Health and Disease (2017) 16:103. DOI 10.1186/s12944-017-0488-4.
  5. Chandrika Jayakanthi Subasinghe, Nirmala Dushyanthi Sirisena, Chula Herath, Knut Erik Berge, Trond Paul Leren, Uditha Bulugahapitiya1 and Vajira Harshadeva Weerabaddana Dissanayake (2017). Novel mutation in the SLC12A3 gene in a Sri Lankan family with Gitelman syndrome & coexistent diabetes: a case report. BMC Nephrology (2017) 18:140 DOI 10.1186/s12882-017-0563-0.
  6. Paul Kruszka, Yonit A. Addissie, Daniel E. McGinn, Antonio R. Porras, Elijah Biggs, Matthew Share, T. Blaine Crowley, Brian H. Y. Chung, Gary T. K. Mok, Christopher C. Y. Mak, Premala Muthukumarasamy, Meow-Keong Thong, Nirmala D. Sirisena, Vajira H. W. Dissanayake, C. Sampath Paththinige, L. B. Lahiru Prabodha, Rupesh Mishra, Vorasuk Shotelersuk, Ekanem Nsikak Ekure, Ogochukwu Jidechukwu Sokunbi, Nnenna Kalu, Carlos R. Ferreira, Jordann-Mishael Duncan, Siddaramappa Jagdish Patil, Kelly L. Jones, Julie D. Kaplan, Omar A. Abdul-Rahman, Annette Uwineza, Leon Mutesa, Angélica Moresco, María Gabriela Obregon, Antonio Richieri-Costa, Vera L. Gil-da-Silva-Lopes, Adebowale A. Adeyemo, Marshall Summar, Elaine H. Zackai, Donna M. McDonald-McGinn, Marius George Linguraru, Maximilian Muenke. (2017). 22q11.2 deletion syndrome in diverse populations. Am J Med Genet. 2017;173:879–888. DOI 10.1002/ajmg.a.38199.
  7. Kruszka P, Porras AR, Sobering AK, Ikolo FA, La Qua S, Shotelersuk V, Chung BHY, Mok GTK, Uwineza A, Mutesa L, Moresco A, Obregon MG, Sokunbi OJ, Kalu N, Joseph DA, Ikebudu D, Ugwu CE, Okoromah CAN, Addissie YA, Pardo KL, Brough JJ, Lee N-C, Girisha KM, Patil SJ, Ng ISL, Min BCW, Jamuar SS, Tibrewal S, Wallang B, Ganesh S, Sirisena ND, Dissanayake VHW, Paththinige CS, Prabodha LBL, Richieri-Costa A, Muthukumarasamy P, Thong M-K, Jones KL, Abdul-Rahman OA, Ekure EN, Adeyemo AA, Summar M, Linguraru MG, Muenke M. (2017). Down syndrome in diverse populations.Am J Med Genet Part A Vol No. 173A:pp.42–53. DOI 10.1002/ajmg.a.38043.
  8. N. D. Sirisena, B. Gautam, N. D. W. Dissanayake, V. H. W. Dissanayake. A case series of three Sri Lankan families with hereditary breast and ovarian cancer syndrome due to pathogenic germline mutations in the BRCA1 gene. Ceylon Medical Journal 2017; 62: 65-66. DOI: http://doi.org/10.4038/cmj.v62i1.8437.
  9. Banstola, S.R., Sirisena, N.D., Sumathipala, D.S., Dissanayake, V.H.W. (2016). A case series of 7 Sri Lankan patients with type 1 spinal muscular atrophy. Sri Lanka Journal of Child Health. Vol No. 45(4); December; pp.247–249. DOI: http://doi.org/10.4038/sljch.v45i4.8029.
  10. Paththinige, C.S., Sirisena, N.D., Kariyawasam, U.G.I.U., Saman Kumara L. P. C., Dissanayake, V.H.W. (2016). Ring Chromosome 4 in a Child with Multiple Congenital Abnormalities: A Case Report and Review of the Literature. Case Reports in Genetics. Article ID 4645716; August; pp.1-7. DOI: 10.1155/2016/4645716.
  11. Kidnapillai, S., Sirisena, N.D., Dissanayake, V.H.W., (2016). HLA-B27 allele frequency in Sri Lankan patients with spondyloarthritides. Ceylon Medical Journal. Vol No. 61(2); June; pp.71–73. DOI: http://doi.org/10.4038/cmj.v61i2.8287.
  12. Kidnapillai, S., Sirisena, N.D., Dissanayake, V.H.W., (2016). Authors’ reply re: HLA-B27 allele frequency in Sri Lankan patients with spondyloarthritides Ceylon Medical Journal. Vol No. 61(4); December; pp.203. DOI: 10.4038/cmj.v61i4.8399.
  13. Sirisena, N.D., Sumathipala, D., Wetthasinghe, K., Dissanayake, V.H.W. (2016). The Provision of Medical and Health Genetics and Genomics in the Developing World. In: Kumar, D. and Antonarakis, S. (ed.) Medical and Health Genomics. Elsevier – Academic Press, Cambridge.
  14. Sirisena, N.D., Neththikumara, N., Wetthasinghe, K., Dissanayake, V.H.W. (2016). Implementation of genomic medicine in Sri Lanka: Initial experience and challenges, Appl. Transl. Genomic. Vol No. 9; June; pp.33-36. http://dx.doi.org/10.1016/j.atg.2016.05.003.
  15. Sirisena, N.D., Dissanayake, V.H.W. (2016). Correspondence: Establishing a relationship between clinical features and one specific type of chromosome abnormality. World Journal of Pediatrics. Vol No. 12 (3); August; pp.374–375. DOI: 10.1007/s12519-016-0007-0.
  16. Sirisena, N.D., Tantrigoda, N.H., Kariyawasam, K.J.C., Jayasekara, R.W., Dissanayake, V.H.W. (2016). Novel AGXT Gene Mutation in a Sri Lankan Family with Primary Hyperoxaluria Type 1. Nephrology. Vol No. 21(1); January; pp.76-77. DOI:10.1111/nep.12572.
  17. K S H de Silva, N D Sirisena, H K Wijenayaka, J G Cooray, R W Jayasekara, V H W Dissanayake. Androgen insensitivity syndrome in a cohort of Sri Lankan children with 46, XY disorders of sex development. Ceylon Medical Journal 2015; 60 (4): 139-142.
  18. Nirmala D Sirisena, Shenal Thalgahagoda, Asiri Abeyagunawardena, Manuela Neumann, Hans‐Otto Schmudlach, Rohan W Jayasekara, Vajira HW Dissanayake. Novel COL4A3 gene mutations in a consanguineous family with autosomal recessive Alport syndrome. Nephrology doi:10.1111/nep.12430, 2015; 20 (8), 580.
  19. PKDCT Somadasa, UND Sirisena, LSC De Silva, VHW Dissanayake. A Sri Lankan family with cerebellar hemangioblastoma due to a heterozygous nonsense mutation in the von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase (VHL) gene. Sri Lanka Journal of Surgery 2015; 33 (1), 30-32.
  20. Sharmila Thillainathan, Nirmala D. Sirisena, K.W. Jayani C. Kariyawasam, Rohan W. Jayasekara, Vajira H.W. Dissanayake. Prevalence of Chromosomal Abnormalities in a Cohort of Sri Lankan Children referred for Cytogenetic Analysis. World J Pediatr Nov 2014: Online First. DOI: 10.1007/s12519-014-0526-5.
  21. K.M.D. Gunathilake, U.N.D. Sirisena, P.K.D. Nisansala, H.W.W. Goonasekera, R.W. Jayasekara, V.H.W. Dissanayake. The Prevalence of the Prothrombin (F2) 20210G>A Mutation in a Cohort of Sri Lankan Patients with Thromboembolic Disorders. Indian Journal of Hematology and Blood Transfusion, September 2014. DOI 10.1007/s12288-014-0452-7.
  22. N.D. Sirisena, K. McElreavey, A. Bashamboo, K.S.H. de Silva, R.W. Jayasekara, V.H.W. Dissanayake. Child with a novel de novo mutation in the Aristaless Domain of the Aristaless-Related Homeobox (ARX) gene presenting with ambiguous genitalia and psychomotor delay. Sex Dev 2014; 8:156–159. DOI: 10.1159/000365458.
  23. U.N.D. Sirisena, V.H.W. Dissanayake. Review - Cancer Genetics and the Surgeon – new frontiers. The Sri Lanka Journal of Surgery 2014; 32(2): 12-19.
  24. Nirmala Sirisena, Niluka Dissanayake, Vajira H.W. Dissanayake. Annex 1 - Hereditary Breast Cancer in Early Detection and Management of Breast Symptoms - National Guideline for Primary Care Doctors and Family Physicians published by the National Cancer Control Programme, Ministry of Health, Sri Lanka, Second Edition January 2014.
  25. Nirmala D. Sirisena, U. Kalpani S. Wijetunge, Ramya de Silva and Vajira H.W. Dissanayake. Child with Deletion 9p Syndrome Presenting with Craniofacial Dysmorphism, Developmental Delay and Multiple Congenital Malformations. Case Reports in Genetics, Volume 2013 (2013), Article ID 785830, 4 pages. http://dx.doi.org/10.1155/2013/785830.
  26. Lasitha Samarakoon, Nirmala D. Sirisena, Kalum T. Wettasinghe, K.W. Jayani C. Kariyawasam, Rohan W. Jayasekara and Vajira H.W. Dissanayake. Prevalence of chromosomal abnormalities in Sri Lankan women with primary amenorrhoea. J. Obstet. Gynaecol. Res. Vol. 39, No. 5: 991-997, May 2013. doi: 10.1111/j.1447-0756.2012.02063.x
  27. Vajira H.W. Dissanayake, Nirmala D. Sirisena, Lakshini Y. Weerasekera, Chumithri G. Gammulla, Harshalal R. Seneviratne and Rohan W. Jayasekara. Candidate Gene Study of Genetic Thrombophilic Polymorphisms in Pre-Eclampsia and Recurrent Pregnancy Loss in Sinhalese Women. J. Obstet. Gynaecol. Res. Vol. 38, No. 9: 1168-1176, September 2012. doi:10.1111/j.1447-0756.2012.01846.x
  28. Kalum T. Wettasinghe, Nirmala D. Sirisena, Prabha H. Andraweera, Rohan W. Jayasekara and Vajira H.W. Dissanayake. A Case Series of Five Sri Lankan Patients with Ovotesticular Disorder of Sex Development. Clin. Paediatr. Endocrinol, 2012; 21(4), 69-73.
  29. M.O. Njoku, N.D. Sirisena, J.A. Idoko, D. Jelpe. CD4+ T-lymphocyte counts in patients with Human Immunodeficiency Virus type 1 (HIV-1) and healthy population in Jos, Nigeria. Niger Postgrad Med J. 2003 Sep; 10(3): 135-9.
  30. E.I. Agaba, P.A. Agaba, N.D. Sirisena, E.A. Anteyi, J.A. Idoko. Renal disease in the acquired immunodeficiency syndrome in north central Nigeria. Niger J Med. 2003 Jul-Sep; 12(3): 120-5.
  31. N.D. Sirisena, M.O. Njoku, J.A. Idoko, E. Isamade, C. Barau, D. Jelpe, A. Zamani, S. Otowo. Carriage rate of hepatitis-B surface antigen (HBsAg) in an urban community in Jos, Plateau State, Nigeria. Niger Postgrad Med J. 2002 Mar; 9(1): 7-10.
  32. Sirisena N.D. The prevalence and clinical pattern of Human Immunodeficiency Virus 1 (HIV-1) infection in Nigerian prisoners. Nigerian Medical Practitioner 2002; 41: 8-14.
  33. Idoko J.A., Njoku M.O., Sirisena N.D. CD4+ T-lymphocyte counts in Human Immunodeficiency Virus (HIV) infected and healthy Nigerian population. Nigerian Medical Practitioner 2001; 39: 53-56.
  34. Hepatitis B surface antigenaemia in patients with Human Immunodeficiency Virus-1 (HIV-1) infection in Jos, Nigeria. ND Sirisena, MO Njoku, JA Idoko. Nigerian Medical Practitioner 2002; 41, 18-20.

 

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Undergraduate

 

  • MBBS course – Embryology, Anatomy, Histology, Genetics
  • BSc Physiotherapy – Genetics
  • BSc Pharmacy – Anatomy

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  • MSc in Clinical Genetics/MSc in Genetic Diagnostics
  • MD Oncology
  • MD Transfusion Medicine
  • Certificate in Basic Laboratory Sciences

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 Department of Anatomy, Faculty of Medicine, University of Colombo, Kynsey Road, Colombo 08, Sri Lanka

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