TMRC – Progress & Achievements

In this section you will find all the achievements we have accomplished so far and the progress of what we have gained through our research project from the beginning.

  • Siriwardana Y, Deepachandi B, Weerasinghe S, Karunaweera N, Udagedara C, Warnasuriya W, Ranawaka RR, Kahawita I. (2021). First Evidence from Sri Lanka for subphenotypic diversity within L. donovani-induced classical cutaneous leishmaniasis. BioMed Research International. 2021: Article ID 3537968. https://doi.org/10.1155/2021/3537968
  • Silva H, Liyanage A, Deerasinghe T, Sumanasena B, Munidasa D, de Silva H, Weerasingha S, Fernandopulle R, Karunaweera ND. (2021).Therapeutic response to thermotherapy in cutaneous leishmaniasis treatment failures for sodium stibogluconate: A randomized controlled proof of principle clinical trial. American Journal of Tropical Medicine and Hygiene. 104(3): 945-950. https://doi.org/10.4269/ajtmh.20-0855
  • Karunaweera ND et al., (2020). Spatial Epidemiologic Trends and Hotspots of Leishmaniasis, Sri Lanka, 2001–2018. Emerging Infectious Diseases. 26(1). https://doi.org/10.3201/eid2601.190971
  • Pathirage DRK et al., (2020). Insecticide susceptibility of the sand fly leishmaniasis vector Phlebotomus argentipes in Sri Lanka. Parasite Vectors 13(1): 246. https://doi.org/10.1186/s13071-020-04117-y
  • Pradhan A, et al., (2020). Atypical presentation of post-kala-azar dermal leishmaniasis in Bhutan. Case Reports in Dermatological Medicine 2020: Article ID 8899586, https://doi.org/10.1155/2020/8899586
  • Ahuja K, et al., (2020). High Resolution Melting based method for rapid discriminatory diagnosis of co-infecting Leptomonas seymouri in Leishmania donovani-induced leishmaniasis. Parasitology International. 75: 102047. https://doi.org/10.1016/j.parint.2019.102047
  • Deepachandi B et al, Quantification of soluble or insoluble fractions of Leishmania parasite proteins in micro-volume applications: a simplification to standard Lowry assay. International Journal of Analytical Chemistry. 2020: 6129132. https://doi.org/10.1155/2020/6129132
  • Siriwardana Y et al., (2019). First Evidence for Two Independent and Different Leishmaniasis Transmission Foci in Sri Lanka: Recent Introduction or Long-Term Existence? Journal of Tropical Medicine https://doi.org/10.1155/2019/6475939
  • Deepachandi B, et al., (2019). A highly sensitive modified nested PCR to enhance case detection in leishmaniasis. BMC Infectious Diseases 19:623. https://doi.org/10.1186/s12879-019-4180-3
  • Ejazi SA et al., (2019). A multicentric evaluation of dipstick test for serodiagnosis of visceral leishmaniasis in India, Nepal, Sri Lanka, Brazil, Ethiopia and Spain. Scientific Reports. 9:9932. https://doi.org/10.1038/s41598-019-46283-9
  • Siriwardana Y, et al., (2019). Leishmania donovani induced cutaneous leishmaniasis: an insight into atypical clinical variants in Sri Lanka. Journal of Tropical Medicine. https://doi.org/10.1155/2019/4538597
  • Siriwardana Y, et al., (2019). Trends in recently emerged Leishmania donovani induced cutaneous leishmaniasis, Sri Lanka, first 13 years. BioMed Research International. Volume 2019, Article ID 4093603, https://doi.org/10.1155/2019/4093603
  • Samarasinghe SR, et al., (2018). Genomic insights into virulence mechanisms of Leishmania donovani: evidence from an atypical strain. BMC Genomics. 28; 19(1):843. https://doi.org/10.1186/s12864-018-5271-z
  • Refai W, et al., (2018). Cutaneous leishmaniasis in Sri Lanka: effect on quality of life. International Journal of Dermatology. https://doi: 10.1111/ijd.14240.
  • Siriwardana YD, et al., (2018). Evidence for seroprevalence in human localized cutaneous leishmaniasis caused by L. donovani in Sri Lanka. Biomed Research International 17; 2018: 9320367. https://doi.org/10.1155/2018/9320367
  • Manamperi NH, et al., (2018). Tissue impression smears as a supplementary diagnostic for histopathology for cutaneous leishmaniasis in Sri Lanka. American Journal of Tropical Medicine and Hygiene. 98(3):759-762. https://doi.org/10.4269/ajtmh.17-0748
  • Kaunaweera ND, Ferreira MU. (2018). Leishmaniasis: Current challenges and prospects for elimination with special focus on the South Asian region. Parasitology. 12:1-5. doi: https://doi.org/10.1017/s0031182018000471
  • Kariyawasam KKGDUL, et al., (2018). Dermotropic Leishmania donovani in Sri Lanka: Visceralizing potential in clinical and preclinical studies. Parasitology. 145(4):443-452. https://doi.org/10.1017/S003118201700169X
  • Kariyawasam KKGDUL, et al., (2017). Genetic diversity of Leishmania donovani that causes cutaneous leishmaniasis in Sri Lanka: a cross sectional study with regional comparisons. BMC Infectious Diseases, 17:791. https://doi.org/10.1186/s12879-017-2883-x
  • Siriwardana HVYD et al., (2017). Emergence of visceral leishmaniasis in Sri Lanka: a newly established health threat. Pathogens and Global Health, 111:6, 317-326. https://doi.org/10.1080/20477724.2017.1361564
  • Manamperi NH, et al., (2017). In situ immunopathological changes in cutaneous leishmaniasis due to Leishmania donovani. Parasite Immunology; 39 (3). https://doi.org/10.1111/pim.12413
  • Refai W et al., (2017). Efficacy, safety and cost-effectiveness of thermotherapy in the treatment of Leishmania donovani-induced cutaneous leishmaniasis: A randomized controlled clinical trial. American Journal of Tropical Medicine and Hygiene, 97(4):1120-1126. https://doi.org/10.4269/ajtmh.16-0879
  • Dr. H.V.Y.D Siriwardana (2008) (the first PhD on leishmaniasis in Sri Lanka)
    Current position: Professor in Parasitology, Faculty of Medicine, Colombo
    Thesis title: Clinical epidemiology of cutaneous leishmaniasis in Sri Lanka and molecular identification of the parasite
  • Dr. T.N Samaranayake (2011)
    Current position: Head of Department and Professor in Parasitology, Faculty of Medicine, Colombo.
    A candidate gene association study of genetic susceptibility to cutaneous leishmaniasis in Sri Lanka
  • Udeshika Kariyawasam (2018)
    Current position: Postdoctoral Scientist, Oklahoma State University, USA.
    Thesis title: Phenotypic and genetic characteristics of Leishnania donovani that cause cutaneous Ieishmaniasis in Sri Lanka
  • Dr. Nuwani H. Manamperi (2018)
    Current position: Senior Lecturer in Parasitology, Faculty of Medicine, University of Kelaniya.
    Thesis title: Host factors in the pathogenesis of cutaneous leishmaniasis due to Leishmania donovani in Sri Lanka.
  • S.A.S.C Senanayake (Ongoing Ph. D. project)
    Current position: Senior Lecturer (Grade I) in Parasitology, Faculty of Medicine, Colombo
    Project Title: Studies on vector of leishmaniasis and its transmission
  • Dr. N.H Silva (Ph. D. project completed)
    Current position: Lecturer (Grade II) in Parasitology, Faculty of Medicine, Colombo
    Project title: Parasite determinants that influence the treatment outcome in cutaneous leishmaniasis in Sri Lanka
  • Dr. Dulani Pathirage (Ph. D. project completed)
    Current position: Research Assistant
    Project title: Phlebotomus argentipes, the vector of leishmaniasis in Sri Lanka; mechanisms and propagation of insecticide resistance.
  • Hasna Riyal (Ongoing Ph. D. project)
    Current position: Research Assistant
    Project title: Host innate immune mechanisms, parasite phenotypes and genetics in pathogenesis of cutaneous leishmaniasis in Sri Lanka.

 

Research grant awarded as an off-shoot of the NIH parent project: CRDF Global, National Institute of Health. Ref. No. 28862 (2019-2021)
Title: Interdisciplinary Study of Factors Related to Treatment Outcome of Sri Lankan Cutaneous Leishmaniasis” was selected to receive the U.S.-Japan Cooperative Medical Sciences Program Collaborative Award, 2019
Principal Investigator: Dr. N.H Silva; Co-Principal Investigator: Prof. N.D. Karunaweera
Amount: USD 45,000 (LKR 8.1 million)

  • Sanath Senanayake (2007)
    Degree: MD (Microbiology with special interest in Parasitology)
    Title: Study on Phlebotomine Sandflies in selected areas of Sri Lanka
    Current position: Senior Lecturer in Parasitology, Faculty of Medicine, Colombo
  • Wardha Refai (2016)
    Degree: MD (Microbiology with special interest in Parasitology)
    Title: Study of behavioural patterns in cutaneous leishmaniasis (CL) and efficacy and cost-effectiveness of a novel treatment method for CL in Sri Lanka
    Current position: Consultant Parasitologist/ Entomologist, Medical Research Institute, Ministry of Healthcare, Sri Lanka.
  • KTGMP Kariyawasam (2016)
    Degree: MD (Community Medicine)
    Title: Cutaneous leishmaniasis: developing a valid and reliable instrument for community-based case detection and epidemiology in Polonnaruwa district
    Current position: Consultant Community Physician, Ministry of Healthcare, Sri Lanka.
  • Hiruni Wijesooriya (2020)
    Title: Role of host innate cellular immune response in infections by L. donovani
    Current position: Project Manager, Tobacco Observatory, Regional office, Colombo.
  • Dr. GSP Ranasinghe (2012)
    Dissertation title: Setting up of a serological assay for diagnosis of leishmaniasis and seroprevalence of anti-leishmania antibodies in patients whose diagnosis has been confirmed through PCR.
    Current Position: Consultant, Medical Administration, Ministry of Health, Colombo.
  • Dr. Kalpani Kumarasiri (2020/2021): Ongoing study.
    Project title: use of molecular methods to study the source of blood meal and Leishmania donovani infection in Phlebotomus argentipes sandflies from selected areas in Sri Lanka